Laboratorije

Rukovodilac laboratorije: ???
Oblast rada: ???

Kontakt telefon: ???
Kontakt el. adresa: ???
Adresa: dr Subotića starijeg 1, Beograd

Godina početka rada: ???

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Rukovodilac laboratorije: ???
Oblast rada: ???

Kontakt telefon: ???
Kontakt el. adresa: ???
Adresa: dr Subotića starijeg 1, Beograd

Godina početka rada: ???

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Rukovodilac laboratorije: ???
Oblast rada: ???

Kontakt telefon: ???
Kontakt el. adresa: ???
Adresa: dr Subotića starijeg 1, Beograd

Godina početka rada: ???

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Projekti:

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Rukovodilac laboratorije: ???
Oblast rada: ???

Kontakt telefon: ???
Kontakt el. adresa: ???
Adresa: dr Subotića starijeg 1, Beograd

Godina početka rada: ???

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Projekti:

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Radovi:

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Rukovodilac laboratorije: Prof. dr Mirjana Platiša
Oblast rada: analiza fizioloških signala, primenjena fizika

Kontakt telefon: + 381 11 3607158, +381 11 3607154
Kontakt el. adresa: mirjana.platisa@gmail.com, mirjana.platisa@med.bg.ac.rs
Adresa: Institut za biofiziku, Medicinski fakultet Univerziteta u Beogradu
KCS PP 22, Višegradska 26-2, 11 129 Beograd, Srbija

Godina početka rada: 2010.

Istraživači:

Doktorandi:

• Nikola Radovanović (2017- ),
• Ana Kapidžić (2012-2015),
• Zoran Matić (2018-2019).

Studenti:

• Tamara Mandić i Ivana Maksimović (2018/19),
• Šućro Madžgalj (2017/18),
• Janko Zeković (2016/17),
• Stefan Preković (2012/13).

Projekti:

• TR 31020 (2011- ) Razvoj tehnologije proizvodnje crvenog vina i dijetetskih proizvoda iz vina bogatih biološki aktivnim polifenolima sa kardioprotektivnim dejstvima
• OI 141042 (2006-2010) Linerarne i nelinearne varijacije srčanih frekvencija

Radovi:

2019.

• Platiša MM, Bojić T, Mazić S, Kalauzi A. Generalized Poincaré plots analysis of heart period dynamics in different physiological conditions: Trained vs. untrained men. PLoS One. 2019 Jul 5;14(7):e0219281. doi: 10.1371/journal.pone.0219281. eCollection 2019.
• Platiša MM, Radovanović NN, Kalauzi A, Milašinović G, Pavlović SU. Differentiation of Heart Failure Patients by the Ratio of the Scaling Exponents of Cardiac Interbeat Intervals. Front Physiol. 2019 May 14;10:570. doi: 10.3389/fphys.2019.00570. eCollection 2019.
• Lakočević MB, Platiša MM, Šumarac ZR, Suvajdžić ND, Mačukanović LĐ, Petakov MS. Peripheral neural response and sex hormones in type 1 Gaucher disease. Journal of Medical Biochemistry 2019 J Med Biochem 2019;38:1-5. doi: 10.2478/jomb-2019-0020.

2018.

• Radovanović NN, Pavlović SU, Milašinović G, Kirćanski B, Platiša MM. Bidirectional Cardio-Respiratory Interactions in Heart Failure. Front Physiol. 2018 Mar 6;9:165. doi: 10.3389/fphys.2018.00165. eCollection 2018.
• Zeković J, Madžgalj Š, Platiša MM. Detrended Fluctuation Analysis of Heart and Respiratory Rhythm in Atrial Fibrilation (Conference Paper) 45th Computing in Cardiology Conference, CinC 2018; Maastricht; Netherlands; 23 September 2018 through 26 September 2018;. doi: 22489/CinC.2018.300.
• Čukić MB, Platiša MM, Kalauzi A, Oommen J, Ljubisavljević M. The comparison of Higuchi fractal dimension and Sample Entropy analysis of sEMG: effects of muscle contraction intensity and TMS. (https://arxiv.org/abs/1803.10753).

2017.

• Platiša MM, Gal V, Nestorović Z, Leskošek-Čukalović I, Despotović S, Veljović M, Petrović A, Rajković J, Đokić V, Naovaković R, Gojković-Bukarica LJ.Changes in linear and nonlinear measures of RR and QT interval series after beer intake. Vojnosanit. Pregl. 2017. 74(12) 1107-1111. doi: 10.2298/VSP150514316P.

2016.

• Platiša MM, Bojić T, Pavlović SU, Radovanović NN, Kalauzi A. Uncoupling of cardiac and respiratory rhythm in atrial fibrilaion. Eng. – Biomed. Tech. 2016; 61(6):657-663. doi: 10.1515/bmt-2016-0057.
• Platiša MM, Bojić T, Pavlović SU, Radovanović NN, Kalauzi A. Generalized Poincaré plots – a new method for evaluation of regimes in cardiac neural control in atrial fibrillation and healthy subjects. Neurosci. 2016; 10:38. doi: 10.3389/fnins.2016.00038

2014.

• Kapidžić A, Platiša MM, Bojić T, Kalauzi A. Nonlinear properties of cardiac rhythm and respiratory signal under paced breathing in young and middle-aged healthy subjects. Medical Engineering & Physics 2014; Dec 36(12):1577-84. doi: 10.1016/j.medengphy.2014.08.007.
• Kapidžić A, Platiša MM, Bojić T, Kalauzi A. RR interval-respiratory signal waveform modeling in human slow paced and spontaneous breathing. Respiratory Physiology & Neurobiology 2014; Nov 1;203:51-9. doi: 10.1016/j.resp.2014.08.004.
• Platiša MM, Gal V, Nestorović Z,Gojković-Bukarica LJ. Quantification of the acute effect of low dose of red wine by nonlinear measures of RR and QT interval series in healthy subjects. Computers in Biology and Medicine 2014; Oct; 53:291-6. doi: 10.1016/j.compbiomed.2014.08.015.

2013.

• Gal V, Platiša MM, Nestorović Z, Labudović-Borović M, Vuksanović V, Gojković-Bukarica LJ. Contractions of the whole and longitudinally cut rat’s portal vein in vitro. Computers in Biology and Medicine 2013; 43(9):1114-1119. doi: 10.1016/j.compbiomed.2013.05.015.

2010.

• Vuksanović V, Gal V, Platisa MM, Gojković-Bukarica L. Spontaneous contractions of isolated rat portal vein under temperature perturbations. Med Biol Eng Comput. 2010 Sep;48(9):887-94. doi: 10.1007/s11517-010-0643-9.

2008.

• Platisa MM, Mazic S, Nestorovic Z, Gal V.Complexity of heartbeat interval series in young healthy trained and untrained men. Physiol Meas. 2008 Apr;29(4):439-50. doi: 10.1088/0967-3334/29/4/002.
• Platisa MM, Gal V. Correlation properties of heartbeat dynamics. Eur Biophys J. 2008 Sep;37(7):1247-52. doi: 10.1007/s00249-007-0254-z.

2006.

• Platisa MM, Gal V. Dependence of heart rate variability on heart period in disease and aging. Physiol Meas. 2006 Oct;27(10):989-98. doi: 10.1088/0967-3334/27/10/005.
• Platisa MM, Gal V. Reflection of heart rate regulation on linear and nonlinear heart rate variability measures. Physiol Meas. 2006 Feb;27(2):145-54. doi: 1088/0967-3334/27/2/005.
• Platisa MM, Nestorovic Z, Damjanovic S, Gal V. Linear and non-linear heart rate variability measures in chronic and acute phase of anorexia nervosa. Clin Physiol Funct Imaging. 2006 Jan;26(1):54-60. doi: 1111/j.1475-097X.2005.00653.x.

2005.

• Platisa MM, Gal V, Damjanović S. Spectral analysis of heart period variability in anorexia nervosa. Vojnosanit Pregl. 2005 Jan;62(1):27-31. doi: 2298/vsp0501027p

Rukovodilac laboratorije: Prof. Dr Dejan Žikić

Oblast rada:Razvoj biomedicinskih senzora, medicinska elektronika, analiza fizioloških signala, biofizičko modelovanje u hemodinamici

Kontakt telefon: +381 11 3607159
Kontakt el. adresa: dejan.zikic@med.bg.ac.rs, dzikic@gmail.com
Adresa: Institut za biofiziku, Medicinski fakultet, Višegradska 26, Beograd

Godina početka rada: 2006

Istraživači:

• Bojana Stojadinović

• Zorica Nestorović

• Biljana Đurić

Projekti:

• 2017-2018. Razvoj uređaja za kontinualno neinvazivno merenje dugotrajno merenje talasnog oblika arterijskog protoka krvi. Inovacioni projekat: 391-00-17/2017-16-RFL 19

• 2010- Akutni koronarni sindrom: studija o ugroženosti (plaka , krvi i miokarda), optimalni tretman i određivanje prognostičkih faktora II41022

• 2010- Razvoj metoda za multivarijantnu analitičku podršku za biomedicinsku dijagnostiku TR32040

• 2008-2009. Razvoj, primena i komercijalizacija senzora za neinvazivno merenje arterijskog protoka krvi Inovacioni projekat: 451-01-00065/2008-01/25

Radovi:

• Patent MP-2012/0063. Poboljšana konstrukcija optičkog senzora za kontinualno merenje arterijskog protoka krvi. Pronalazač Dejan Žikić, Glasnik intelektualne svojine 2013/03

• D. Žikić, B. Stojadinović and Z. Nestorović, 2019. Biophysical modeling of wave propagation phenomena: experimental determination of pulse wave velocity in viscous fluid-filled elastic tubes in a gravitation field European Biophysics Journal with Biophysics Letters 48(5): 407-411

• B. Djurić,S. Suzić, B. Stojadinović, Z. Nestorović, M. Ivanović, J. Suzić-Lazić, D. Nešić, S. Mazić, T. Tenne, D. Zikich and D. Žikić, 2017. An improved design of optical sensor for long-term measurement of arterial blood flow waveform. Biomed Microdevices 19:48.

• D. Žikić, 2017. A mathematical model of pressure and flow waveforms in the aortic root. European Biophysics Journal with Biophysics Letters 46 (1): 41-48.

• B. Stojadinović, Z. Nestorović, B. Djurić, T. Tenne, D. Zikich and D. Žikić, 2017. Laboratory model of the cardiovascular system for experimental demonstration of pulse wave propagation. Physics Education 52

• B. Lazovic-Popovic, M. Zlatkovic-Svenda, M. Djelic, T. Durmic, D. Zikic, V. Zugic, 2016. Is there relationship between dynamic volumes of pulmonary function and cardiac workload (maximal oxygen uptake) in young athletes? Revista Portuguesa de Pneumologia 22(4): 237–240

• Durmic T, Lazovic B, Djelic M, Lazic JS, Zikic D, Zugic V, Dekleva M, Mazic S, 2015. Sport-specific influences on respiratory patterns in elite athletes. J Bras Pneumol. 41(6):516-22.

• B. Stojadinović, T. Tenne, D. Zikich, N. Rajković, N. Milošević, B. Lazović, D. Žikić, 2015. Effect of viscosity on the wave propagation: Experimental determination of compression and expansion pulse wave velocity in fluid-fill elastic tube. Journal of Biomechanics 48(15): 3969-3974.

• M. Djelić, S. Mazić, B. Lazović, D. Žikić, M. Šumarac-Dumanović & D. Micić, 2015. Carbohydrate and fatty acid metabolism responses to a graded maximal exercise test and recovery period in athletes and sedentary subjects. Science & Sports. 30(6): 321-327.

• B. Lazović, S. Mazić, D. Zikich & D. Žikić, 2015. The mathematical model of the radial artery blood pressure waveform through monitoring of the age-related changes. Wave Motion 56:14-21.

• S. Mazić, B. Lazović, M. Djelić, J. Suzić-Lazić, S. Djordjević-Šaranović, T. Acimović, I. Soldatović, D. Žikić, Z. Gluvić, V. Žugić, 2015. Respiratory parameters in elite athletes – does sport have an influence? Revista Portuguesa de Pneumologia, Portuguese Journal of Pulmonology. 21(4):192-197

• S. Mazić, B. Lazović, J. Suzić-Lazić, M. Djelić, S. Djordjević-Šaranović, T. Durmić, D. Žikić, V. Žugić. 2015. Respiratory adaptations in different types of sport. European Review for Medical and Pharmacological Sciences 19(12):2269-2274.

• M. Djelić, S. Mazić & D Žikić, 2013. A novel laboratory approach for the demonstration of hemodynamic principles: the arterial blood flow reflection. Advan in Physiol Edu 37:321-326

• D. Zikich & D. Zikic, 2010. A novel mathematical approach for blood flow signal analyzes. Biological Rhythm Research. 41(6), 487-496.

• D. Žikić, 2008. An improved reflective photoplethysmograph probe design for detection of an arterial blood flow. Journal of Medical Engineering & Technology 32:23-29.

• D. Zikich & D. Zikic, 2008. Arterial Blood Flow Sensor. IFMBE Proceedings (22)1158–1162.

• D. Žikić, 2006. Respiratory sinus arrhythmia as a second order system. Biological Rhythm Research. 37:265-271.

• D. Žikić, V. Gal and S. Božinović, 2000. Two types of cardiovascular autonomic regulatory responses to the war. Int. J. Psychophysiology. 36:247-250.

Rukovodilac laboratorije: Prof dr Nina Japundžić-Žigon

Oblast rada:  Kardiovaskularna farmakologija i toksikologija

Kontakt telefon: +381 11 26 85 997
Kontakt el. adresa: nina.zigon@med.bg.ac.rs
Adresa: Dr Subotića 1, Beograd

Godina početka rada: 2002.

Istraživači:

• Olivera Šarenac
• Maja Lozić
• Tatjana Tasić
• Marko Vasić
• Mirjana Jovanović
• Bojana Stevanović
• Marija Kosić
• Vladislav Pajović

Projekti:

• 2002-2005 Ministrastvo nauke, RS
• 2002-2004 Royal Society, UK
• 2003-2007 Wellcome Trust, UK
• 2005-2010 Ministrastvo nauke, RS
• 2008-2010 Royal Society, UK
• 20017-2019 Bilaterlani projekta sa medicnskim fakuletetom univerziteta Semmelweis, Mađarska
• 2010-2020 Ministarstvo prosvete, nauke i tehnološkog razvoja RS

Radovi:

Vasopressin & Oxytocin in Control of the Cardiovascular System: An Updated Review.

Japundžić-Žigon N, Lozić M, Šarenac O, Murphy D. Curr Neuropharmacol. 2020;18(1):14-33. doi: 10.2174/1570159X17666190717150501.

The influence of subchronic co-application of vitamins B6 and folic acid on cardiac oxidative stress and biochemical markers in monocrotaline-induced heart failure in male Wistar albino rats. Jakovljevic Uzelac J, Djukic T, Mutavdzin S, Stankovic S, Labudovic Borovic M, Rakocevic J, Milic N, Savic Radojevic A, Vasic M, Japundzic Zigon N, Simic T, Djuric D. Can J Physiol Pharmacol. 2019:1-10. doi: 10.1139/cjpp-2019-0305

Cardiovascular variability and β-ARs gene expression at two stages of doxorubicin – Induced cardiomyopathy. Vasić M, Lončar-Turukalo T, Tasić T, Matić M, Glumac S, Bajić D, Popović B, Japundžić-Žigon N. Toxicol Appl Pharmacol. 2019;362:43-51. doi: 10.1016/j.taap.2018.10.015.

Near-Infrared Activatable Phthalocyanine-Poly-L-Glutamic Acid Conjugate: Enhanced in Vivo Safety and Antitumor Efficacy toward an Effective Photodynamic Cancer Therapy.

Cheah HY, Gallon E, Dumoulin F, Hoe SZ, Japundžić-Žigon N, Glumac S, Lee HB, Anand P, Chung LY, Vicent MJ, Kiew LV. Mol Pharm. 2018;15(7):2594-2605. doi: 10.1021/acs.molpharmaceut.8b00132.

The effects of aging on biosynthetic processes in the rat hypothalamic osmoregulatory neuroendocrine system. Greenwood MP, Greenwood M, Romanova EV, Mecawi AS, Paterson A, Sarenac O, Japundžić-Žigon N, Antunes-Rodrigues J, Paton JFR, Sweedler JV, Murphy D. Neurobiol Aging. 2018;65:178-191. doi: 10.1016/j.neurobiolaging.2018.01.008.

Vasopressin, Central Autonomic Control and Blood Pressure Regulation.

Lozić M, Šarenac O, Murphy D, Japundžić-Žigon N. Curr Hypertens Rep. 2018 Feb 26;20(2):11. doi: 10.1007/s11906-018-0811-0. Review.

Sudden death: Neurogenic causes, prediction and prevention. Japundžić-Žigon N, Šarenac O, Lozić M, Vasić M, Tasić T, Bajić D, Kanjuh V, Murphy D. Eur J Prev Cardiol. 2018 Jan;25(1):29-39. doi: 10.1177/2047487317736827. Review.

Preclinical safety assessments of nano-sized constructs on cardiovascular system toxicity: A case for telemetry. Cheah HY, Kiew LV, Lee HB, Japundžić-Žigon N, Vicent MJ, Hoe SZ, Chung LY.

J Appl Toxicol. 2017 Nov;37(11):1268-1285. doi: 10.1002/jat.3437. Review.

Dependency Structures in Differentially Coded Cardiovascular Time Series. Tasic T, Jovanovic S, Mohamoud O, Skoric T, Japundzic-Zigon N, Bajic D. Comput Math Methods Med. 2017;2017:2082351. doi: 10.1155/2017/2082351.

Hemodynamic effects of HPMA copolymer based doxorubicin conjugate: A randomized controlled and comparative spectral study in conscious rats. Cheah HY, Šarenac O, Arroyo JJ, Vasić M, Lozić M, Glumac S, Hoe SZ, Hindmarch CC, Murphy D, Kiew LV, Lee HB, Vicent MJ, Chung LY, Japundžić-Žigon N. Nanotoxicology. 2017;11(2):210-222. doi: 10.1080/17435390.2017.1285071.

Static magnetic field reduces blood pressure short-term variability and enhances baro-receptor reflex sensitivity in spontaneously hypertensive rats. Tasić T, Djordjević DM, De Luka SR, Trbovich AM, Japundžić-Žigon N. Int J Radiat Biol. 2017;93(5):527-534. doi: 10.1080/09553002.2017.1276307.

Binarized cross-approximate entropy in crowdsensing environment. Skoric T, Mohamoud O, Milovanovic B, Japundzic-Zigon N, Bajic D. Comput Biol Med. 2017 Jan 1;80:137-147. doi: 10.1016/j.compbiomed.2016.11.019.

Over-expression of V1A receptors in PVN modulates autonomic cardiovascular control. Lozić M, Tasić T, Martin A, Greenwood M, Šarenac O, Hindmarch C, Paton JF, Murphy D, Japundžić-Žigon N. Pharmacol Res. 2016;114:185-195. doi: 10.1016/j.phrs.2016.10.024.

Effects of IL-33/ST2 pathway in acute inflammation on tissue damage, antioxidative parameters, magnesium concentration and cytokines profile. Stankovic MS, Janjetovic K, Velimirovic M, Milenkovic M, Stojkovic T, Puskas N, Zaletel I, De Luka SR, Jankovic S, Stefanovic S, Japundzic-Zigon N, Petronijevic ND, Trajkovic V, Trbovich AM. Exp Mol Pathol. 2016;101(1):31-7. doi: 10.1016/j.yexmp.2016.05.012.

Blood pressure and pulse interval coupling: A copula approach. Bajic D, Loncar-Turukalo T, Skoric T, Japundzic-Zigon N. Conf Proc IEEE Eng Med Biol Soc. 2015;2015:7696-9. doi: 10.1109/EMBC.2015.7320175.

Overexpression of oxytocin receptors in the hypothalamic PVN increases baroreceptor reflex sensitivity and buffers BP variability in conscious rats. Lozić M, Greenwood M, Šarenac O, Martin A, Hindmarch C, Tasić T, Paton J, Murphy D, Japundžić-Žigon N. Br J Pharmacol. 2014;171(19):4385-98. doi: 10.1111/bph.12776.

Vasopressin and oxytocin in control of the cardiovascular system. Japundžić-Žigon N. Curr Neuropharmacol. 2013;11(2):218-30. doi: 10.2174/1570159X11311020008.

Evidence for involvement of central vasopressin V1b and V2 receptors in stress-induced baroreflex desensitization. Milutinović-Smiljanić S, Šarenac O, Lozić-Djurić M, Murphy D, Japundžić-Žigon N.

Br J Pharmacol. 2013;169(4):900-8. doi: 10.1111/bph.12161.

Unbiased entropy estimates in stress: a parameter study. Boskovic A, Loncar-Turukalo T, Sarenac O, Japundzic-Zigon N, Bajic D. Comput Biol Med. 2012;42(6):667-79. doi: 10.1016/j.compbiomed.2012.03.003.

Autonomic mechanisms underpinning the stress response in borderline hypertensive rats. Šarenac O, Lozić M, Drakulić S, Bajić D, Paton JF, Murphy D, Japundžić-Žigon N. Exp Physiol. 2011;96(6):574-89. doi: 10.1113/expphysiol.2010.055970.

Environmental stress: approximate entropy approach revisited. Loncar-Turukalo T, Bajic D, Sarenac O, Japundzic-Zigon N, Boskovic A. Conf Proc IEEE Eng Med Biol Soc. 2009;2009:1804-7. doi: 10.1109/IEMBS.2009.5332762.

Temporal analysis of the spontaneous baroreceptor reflex during mild emotional stress in the rat.

Bajić D, Loncar-Turukalo T, Stojicić S, Sarenac O, Bojić T, Murphy D, Paton JF, Japundzić-Zigon N.

Stress. 2010;13(2):142-54. doi: 10.3109/10253890903089842.

Cardiovascular response to acute stress in freely moving rats: time-frequency analysis. Loncar-Turukalo T, Bajic D, Japundzic-Zigon N. Conf Proc IEEE Eng Med Biol Soc. 2008;2008:2614-7. doi: 10.1109/IEMBS.2008.4649736.

The role of central vasopressin receptors in the modulation of autonomic cardiovascular controls: a spectral analysis study. Milutinović S, Murphy D, Japundzić-Zigon N. Am J Physiol Regul Integr Comp Physiol. 2006;291(6):R1579-91. doi: 10.1152/ajpregu.00764.2005.

Central vasopressin V(1a) and V(1b) receptors modulate the cardiovascular response to air-jet stress in conscious rats. Stojicić S, Milutinović S, Sarenac O, Zivković S, Japundzić-Zigon N. Biomed Tech (Berl). 2006 Oct;51(4):268-71. doi: 10.1515/BMT.2006.053

Central cholinergic modulation of blood pressure short-term variability. Milutinović S, Murphy D, Japundzić-Zigon N. Neuropharmacology. 2006 Jun;50(7):874-83. doi: 10.1016/j.neuropharm.2005.12.009

Effects of nonpeptide and selective V1 and V2 antagonists on blood pressure short-term variability in spontaneously hypertensive rats. Japundzić-Zigon N, Milutinović S, Jovanović A.

J Pharmacol Sci. 2004 May;95(1):47-55. DOI: 10.1254/jphs.95.47

Rukovodilac laboratorije: Prof. dr Dragan M. Đurić
http://www.heartacademy.org/newsletter/18/3.pdf

Oblast rada: kardiovaskularna fiziologija i patofiziologija, eksperimentalni modeli kardiovaskularnih oboljenja, kardiovaskularna protekcija

 

Kontakt telefon: +381 11 3607112
Kontakt el. adresa: dragan.djuric@med.bg.ac.rs
Adresa: Institut za medicinsku fiziologiju „Rihard Burijan“, ul. Višegradska 26-2, 11129 Beograd, Srbija

Godina početka rada: 1989.

Istraživači:

• Prof. dr Dragan M. Đurić (1989-i dalje)
• Prof. dr Vladimir Jakovljević, Fakultet medicinskih nauka Univerziteta u Kragujevcu (2004-i dalje)
• Dr Jovana Jakovljević Uzelac (2012-i dalje)
• Dr Slavica Mutavdžin (2015-i dalje)
• Dr Radmila Obrenović (2015-i dalje)
• Prof. dr Kristina Gopčević (2016-i dalje)
• Dr Sanja Stanković (2016-i dalje)

Prethodni straživači:

• Prof. dr Ivan Anđelković (1989-2002)
• Prof. dr Mirko Rosić, Fakultet medicinskih nauka Univerziteta u Kragujevcu
• Prof. dr Zvezdana Kojić
• Prof. dr Gvozden Rosić, Fakultet medicinskih nauka Univerziteta u Kragujevcu
• Prof. dr Biljana Miličić, Stomatološki fakultet Univerziteta u Beogradu
• Dr Aleksandra Stamenković, Biološki fakultet Univerziteta u Beogradu

Doktorandi:

• Dr Jovana Jakovljević Uzelac (2012-i dalje)
• Dr Slavica Mutavdžin (2015-i dalje)
• Dr Dušan Todorović (2019-i dalje)
• Dr Marko Đurić (2015-2020)
• Dr Ana Stevanović (2014-i dalje)
• Dr Predrag Đurić (2020, odbranio tezu)
• Dr Tanja Šobot (2019, odbranila tezu)
• Dr Žarko Mićović (2019, odbranio tezu)
• Dr Dragana Aleksić (2013, odbranila tezu)
• Dr Mirjana Veselinović (2012, odbranila tezu)

Studenti:

• Nina Gatarić (2019-i dalje)
• Nebojša Brezić (2018-i dalje)
• Sanja Kostić (2016-2020)
• Jelena Ćuk (2016)
  
• Adi Hadžibegović (2015-2017)
• Stefan Živković (2009-2014)
• Ana Marinković (2013)
• Miona Šokorac (2012)
• Sanja Tegeltija (2011)
• Aleksandra Nikolić (2011)
• Lea Mascarell Maričić (2011)
• Natalija Odanović (2011)
• Maja Velinović (2009)
• Ivan Fufanović (2009)
• Iris Elezović (2009)
• Milan Dobrić (2004-2005)
• Nenad Tomić (2004-2005)
• Jelena Popović (2004)
• Sindi Mitrović (2004)

Projekti:

Domaći:

• 2011-2019 „Efekti homocisteina i homocisteinu-srodnih supstanci na kardiovaskularni sistem: uloga gasotransmitera (lat. NO, CO, H2S)“ (rukovodilac projekta, rukovodilac projekta Prof. dr Dragan Đurić)
• 2006-2010 „Vaskularni zid, faktori rizika i oksidativni stres: od molekula do fiziološke osnove prevencije i terapije“(br. 145014 G rukovodilac projekta, rukovodilac projekta Prof. dr Dragan Đurić)
• 2005 „Vaskularni zid, faktori rizika i oksidativni stres: od molekula do fiziološke osnove prevencije i terapije“(br. 135003, rukovodilac projekta Prof. dr Dragan Đurić)
• 2002-2005 „Eksperimentalni modeli u patogenezi kardiovaskularnih i bubrežnih bolesti“
• 1996-2001 „Funkcije endotela u ishemiji i reperfuziji“ 
• 1989-1996 „Glukagon i kardiovaskularni sistem; efekti glukagona na oslobađanje histamina“  i „Uticaj glukagona na kardiovaskularni sistem-kardiostimulatorno, antiaritmijsko i hemodinamsko delovanje“

Međunarodni:

• 2019-2023 COST action [CA18216] „Network for research in vascular aging (VascAgeNet)“
• 2017-2021 COST action [CA16225 RS] “Realising the therapeutic potential of novel cardioprotective therapies (EUCARDIOPROTECTION)
• 2011-2015 COST action  [BM1005 Biomedicine and Molecular Biosciences] “Gasotransmitters: from basic science to therapeutic applications (ENOG: European Network on Gasotransmitters)

Radovi:

Rukovodilac laboratorije: Prof dr Zvezdana Kojić
Oblast rada: analiza potrošnje kiseonika u izolovanim mitohondrijama i permealizovanim animalnim i humanim ćelijama u fiziološkim i patofiziološkim uslovima; polarografija.

Kontakt telefon: 011-3607-105, 011-3607-093
Kontakt el. adresa: zvezdana.kojic@med.bg.ac.rs, kojic.zvezdana@gmail.com
Adresa: Višegradska 26, 11000 Beograd

Godina početka rada: 1992

Istraživači:

• Marija Milivojević
• Petar Vidović

Projekti:

• 2011- …: Sinteza, razvoj, tehnologija dobijanja i primena nanostrukturnih multifunkcionalnih materijala definisanih svojstava.
• 2006-2010: Azot monoksid – ciklični guanozin monofosfat zavisni mehanizmi u regulaciji steroidogeneze Lajdigovih ćelija.
• 2001- 2006: Koronarna ateroskleroza – rana detekcija, procena hemodinamskog značaja i biološke aktivnosti.

Radovi:

• Kojic ZZ, Flogel U, Schrader J, Decking UK. Endothelial NO formation does not control myocardial O2 consumption in mouse heart. Am J Physiol Heart Circ Physiol. 2003 Jul; 285(1): H392-7. Epub 2003 Feb 2. doi: 10.1152/ajpheart.00836.2002.
• Kojić Z, Sćepanović L, Popović N. Myocardial oxygen consumption regulation in isolated mouse heart: assessment by intracoronary administration of exogenous nitric oxide. Acta Physiol Hung. 2006 Dec; 93(4):263-70. PMID: 17191658
• Kojić Z, Delić M, Bosnić O, Sćepanović L. Possible inhibitory effect of nitric oxide donor, dipropylenetriamine nonoate (DPTA/NO), on oxygen consumption of isolated rats’ testis interstitial cells. Med Pregl. 2008 Jan-Feb;61(1-2):33-6. PMID:18798471
• Kojić Z, Scepanovic LJ, Kostić T. Immobilization stress reduces oxygen consumption of the isolated interstitial rats’ testes cells. Acta Physiol Hung. 2011 Mar; 98(1):45-50. doi: 10.1556/APhysiol.98.2011.1.6.
• Kojic Z, Gopcevic K, Marinkovic D, Tasic G. Effect of captopril on serum lipid levels and cardiac mitochondrial oxygen consumption in experimentally-induced hypercholesterolemia in rabbits. Physiol Res. 2011;60 Suppl 1:S177-84. Epub 2011 Jul 19. PMID: 21777025
• Andric SA, Kojic Z, Bjelic MM, Mihajlovic AI, Baburski AZ, Sokanovic SJ, Janjic MM, Stojkov NJ, Stojilkovic SS, Kostic TS. The opposite roles of glucocorticoid and α1-adrenergic receptors in stress triggered apoptosis of rat Leydig cells. Am J Physiol Endocrinol Metab. 2013 Jan 1;304(1):E51-9. doi: 10.1152/ajpendo.00443.2012
• Kojić ZZ. Animal models in the study of atherosclerosis. Srp Arh Celok Lek. 2003 May-Jun;131(5-6):266-70.
• Arsenijević L, Popović N, Kojić Z. The assessment of severity of lung injury in sepsis. Srp Arh Celok Lek. 2004 Nov-Dec;132(11-12):404-8.
• Popović N, Kojić Z, Bumbasirević V, Pavlović A, Stefanović B, Karamarkovíc A, Radenković D, Nikolić V. Determination of beta-endorphin plasma concentrations in surgical patients with acute abdominal pain. Acta Chir Iugosl. 2004;51(3):51-5.
• Karamarković A, Milić N, Djukić V, Radenković D, Jeremić V, Bumbasirević V, Popović N, Kojić Z, Bajec Dj. Intrahepatic B3 cholangiojejunostomy in the palliative surgery of high unresectable malignant biliary obstruction. Acta Chir Iugosl. 2004;51(3):85-91. PMID:16018372
• Arsenijević L, Kojić Z, Popović N. Plasma levels of cortisol and opioid peptide beta-endorphin during spontaneous vaginal delivery. Srp Arh Celok Lek. 2006 Mar-Apr; 134(3-4):95-9. PMID:16915748
• Kojić Z, Arsenijević L, Sćepanović L, Popović N. Labor pain – physiological basis and regulatory mechanisms. Srp Arh Celok Lek. 2007 Mar-Apr;135(3-4):235-9. PMID:17642469
• Popović N, Blagojević Z, Nikolić V, Arsenijević Lj, Karamarković A, Stefanović B, Kojić Z. Massive hemorrhage and mechanisms of coagulopathy in trauma. Acta Chir Iugosl. 2006;53(4):89-92. PMID:17688041.
• Arsenijević L, Popović N, Kojić Z, Stefanović S, Filimonović D, Karamarković A.
• Central venous catheter-related infections: risk factors and effects of glycopeptide antibiotics. Med Pregl. 2007 Jan-Feb;60(1-2):71-5. PMID: 17853715
• Radulović DV, Tasić GM, Nikolić IM, Joković MB, Repac NR, Cvrkota IS, Kojić Z. Development of new intracranial saccular aneurysms. Acta Chir Iugosl. 2008;55(2):47-9.PMID: 18792573.
• Milojević TM, Baljozović BV, Rakić MLj, Nestorović BD, Dostanić MM, Milaković BD, Kojić ZZ, Repac NR, Cvrkota IS. Cerebral vasospasm after subarachnoid hemorrhage. Acta Chir Iugosl. 2008;55(2):55-60. PMID: 18792575
• Dostanic MM, Stosić MM, Milaković BD, Baljozović BV, Jovanović IB, Kojić ZZ, Marinković DM, Marković DJ, Milić IS. New trends in neuromonitoring patients with aneurysmal subarachnodal haemorrhage. Acta Chir Iugosl. 2008;55(2):69-74. PMID: 18792577
• Danilović LR, Milaković BD, Dostanić MM, Stoić MM, Baljozović BV, Kojić Z, Marinković DM, Marković DJ. Difference between values of gas analysis of arteries and internal jugular vein in patients with cerebral infarction. Acta Chir Iugosl. 2008;55(2):151-9. PMID:18792589
• Kojic Z, Stojanovic D, Popadic S, Jokanovic M, Janackovic D. The irritative property of alpha-tricalcium phosphate to the rabbit skin. Gen Physiol Biophys. 2009;28:168-73. PMID:19893096
• Kojic ZZ, Dewhurst DG. The impact of introducing computer-based alternatives to the use of animals in the teaching of physiology and pharmacology at Balkan universities – a pilot study. Altern Lab Anim. 2009 Nov;37(5):547-56. PMID: 20017583
• Dewhurst DG, Kojic ZZ. Replacing animal use in physiology and pharmacology teaching in selected universities in Easter Europe – charting a way forward. Altern Lab Anim. 2011 Mar; 39(1):15-22. PMID: 21452911.
• Veljović D, Colić M, Kojić V, Bogdanović G, Kojić Z, Banjac A, Palcevskis E, Petrović R, Janaćković D. The effect of grain size on biocompatibility, cell-materials interface, and mechanical properties of microwave-sintered bioceramics. J Biomed Mater Res A. 2012 Nov;100(11):3059-70. doi: 10.1002/jbm.a.34225.
• Nikolic I, Tasic G, Bogosavljevic V, Nestorovic B, Jovanovic V, Kojic Z, Djoric I, Djurovic B. Predictable morphometric parameters for rupture of intracranial aneurysms – a series of 142 operated aneurysms. Turk Neurosurg. 2012;22(4):420-6. doi: 10.5137/1019-5149
• Pantic I, Basta-Jovanovic G, Starcevic V, Paunovic J, Suzic S, Kojic Z, Pantic S. Complexity reduction of chromatin architecture in macula densa cells during mouse postnatal development. Nephrology (Carlton). 2013 Feb;18(2):117-24. doi: 10.1111/nep.12003.
• Kojić Z, Stojanović D. Pathophysiology of migraine – from molecular to personalized medicine. Med Pregl. 2013 Jan-Feb; 66(1-2):53-7. PMID:23534301
• Nikolć I, Tasić G, Antunović V, Rakić M, Mihajlović M, Joković M, Stojisavljević M, Kojić Z, Radlović V, Djurović B, Ducić S. Comparative analysis of the animal model and results of the clinical research of the aneurysm inclination angle as the predisposing factor for the occurrence of rupture. Srp Arh Celok Lek. 2013;141(3-4):150-4. PMID: 23745335

Rukovodilac laboratorije: Prof. dr Predrag Brkić
Oblast rada: Ispitivanje efekata primene molekulskog kiseonika pod povišenim pritiskom, kao terapijskog sredstva, na različitim eksperimentalnim modelima.

Kontakt telefon: 99 381 11 36 07 076
Kontakt el. adresa: predrag.brkic@med.bg.ac.rs
Adresa: Višegradska 26/2 Beograd, Srbija

Godina početka rada: /

Istraživači:

• /

Projekti:

• Od 2011. godine na interdisciplinarnom integracionom projektu br. 41014 pod nazivom “Ćelijske i molekulske osnove neuroinflamacije: potencijalna ciljna mesta za translacionu medicinu i terapiju“, koji je organizovan pod pokroviteljstvom Ministarstva za Nauku i Tehnološki razvoj, rukovodilac je bila Prof. Dr Mirjana Stojiljković, aktuelni rukovodilac je N.S. Sanja Peković sa Instituta za biološka istraživanja „Siniša Stanković“, Univerziteta u Beogradu.

Odabrani radovi:

• Peković S., Dacić S., Krstić D., Jeremić R., Đelić M., Brkić P.: Hyperbaric oxygen therapy in traumatic brain injury: cellular and molecular mechanisms. org/10.5772/intechopen75025: 25-46. U Drjenačević I.: Hyperbaric Oxygen Treatment in Research and Clinical Practice. InTechOpen 2018. ISBN 978-953-51-5916-2.
• Lavrnja I., Parabucki A., Brkic P., Jovanovic T., Dacic S., Savic D., Pantic I., Stojiljkovic M., Pekovic S. Repetitive Hyperbaric Oxygenation Attenuates Reactive Astrogliosis and Suppresses Expression of Inflammatory Mediators in the Rat Model of Brain Injury. Mediat Inflam. 2015, Article ID 498405,doi:10.1155/2015/498405. M22 IF 3,418
• Brkic P., Pekovic S., Krstic D., Jovanovic T. Hyperbaric oxygenation as an adjuvant therapy for traumatic brain injury: a review of literature. Period Biol. 2014;116(1):29-36. M23 IF 0,139
• Parabucki A., Bozic I., Bjelobaba I., Lavrnja I., Brkic P., Jovanovic T., Savic D., Stojiljkovic M., Pekovic S. Hyperbaric oxygenation alters temporal expression pattern of superoxide dismutase 2 after cortical stab injury in rats. Croat Med J. 2012;53(6):586-97. M22 IF 1,250
• Brkić P., Stojiljković M., Jovanović T., Dacić S., Lavrnja I., Savić D., Parabucki A., Bjelobaba I., Rakić Lj., Peković S.: Hyperbaric oxygenation improuves locomotor abilities by enhancing neuroplastic resonses after cortical ablation in rats. Brain Injury. 2012;26(10):1273-1284. M22 IF 1,513

Rukovodilac laboratorije: Prof. dr Ljiljana Šćepanović
Oblast rada: Ispitivanje motorike različitih segmenata digestivnog trakta, efekti sumporovitih aminokiselina na oksidativni status u homogenatu tkiva digestivnog trakta

Kontakt telefon: 011-3607079
Kontakt el. adresa: ljiljana.scepanovic@med.bg.ac.rs, scepanoviclj@gmail.com
Adresa: Višegradksa 26, 11 000 Beograd

Godina početka rada: 1990

Istraživači:

• Prof. dr Ljiljana Šćepanović
• Prof. dr Dušan Mitrović
• Doc. dr Marija Stojanović
• Asist. dr Dušan Todorović

Projekti:

• 2011-i dalje „Efekti homocisteina i homocisteinu-srodnih supstanci na kardiovaskularni sistem: uloga gasotransmitera (lat. NO, CO, H2S)” Rukovodilac projekta: Prof. Dr Dragan Đurić

Radovi:

• Šćepanović V, Tasić G, Repac N, Nikolić I, Janićijević A, Todorović D, Stojanović M, Šćepanović R, Mitrović D, Šćepanović T, Borozan S, Šćepanović L. The role of oxidative stress as a risk factor for rupture of posterior inferior cerebellar artery aneurysms. Mol Biol Rep. 2018. doi: 10.1007/s11033-018-4374-6. [Epub ahead of print]. (M23, IF=1,889)
• Stojanović M, Todorović D, Šćepanović Lj, Mitrović D, Borozan S, Dragutinović V, Borović ML, Krstić D, Čolović M, Djuric D. Subchronic methionine load induces oxidative stress and provokes biochemical and histological changes in the rat liver tissue. Mol Cell Biochem. 2018; 448(1-2): 43-50. doi: 10.1007/s11010-018-3311-2. (M23, IF=2,669)
• Stojanović M, Šćepanović L, Todorović D, Mitrović D, Šćepanović V, Šćepanović R, Ilić S, Šćepanović T, Borović ML, Milićević Ž, Dragutinović V, Borozan S, Lalić I, Despotović S, Djuric D. Suppression of methionine-induced colon injury of young rats by cysteine and N-acetyl-L-cysteine. Mol Cell Biochem. 2018; 440(1-2): 53-64. doi: 10.1007/s11010-017-3155-1. (M23, IF=2,669)
• Stojanović M, Šćepanović Lj, Mitrović D, Šćepanović V, Šćepanović R, Djuric M, Ilić S, Šćepanović T, Djuric D. Different pathways involved in stimulatory effects of homocysteine on rat duodenal smooth muscle. Acta Vet-Beograd. 2017; 67 (2): 254-270. DOI:10.1515/acve-2017-0021 (M22, IF=0,741)
• Stojkovic Lalosevic M, Stojkovic M, Naumovic T, Culafic Dj, Stojanovic M, Stulic M, Alempijevic T, Pavlovic Markovic A. Clinical scores for the prediction of esophageal varices in patients with liver cirrhosis. Acta Gastroenterol Belg. 2016; 79(1): 14-7. (M23, IF=0,912)
• Stojanovic M, Šćepanović Lj, Bosnić O , Mitrović D, Jozanov-Stankov O, Šćepanović V, Šćepanović R, Stojanović T, Ilić S, Djuric D. The effects of the acute administration of D,L-homocysteine thiolactone on antioxidative status of rat intestine and liver. Acta Vet-Beograd. 2016; 66(1): 26-36. DOI: 10.1515/acve-2016-0002 (M23, IF= 0,375)
• Stojanović M, Šćepanović Lj, Hrnčić D, Rašić-Marković A, Djurić D, Stanojlović O. Multidisciplinary approach to nitric oxide signaling: focus on gastrointestinal and central nervous system. Vojnosanit Pregl. 2015; 72(7): 619-624. DOI: 10.2298/VSP131025051S (M23, IF=0,292)
• Stojanović M, Šćepanović Lj, Mitrović D, Šćepanović V, Stojanović T, Stojković M, Ilić S, Đurić D. Rat duodenal motility in vitro: procinetic effects of D,L-homocysteine thiolactone and modulation of nitric oxide mediated inhibition. Arch Biol Sci. 2013; 65 (4): 1323-1330. DOI:10.2298/ABS1304323S (M23, IF= 0,791)
• Hadži Tanović L, Todorović D, Stojanović M, Šćepanović Lj, Djuric D. Protektivni uticaj N-acetil-L-cisteina na efekte stimulacije metioninom u kolonu pacova. Medicinski podmladak. 2016; 67(2): 80-84. (M52)
• Micovic Z, Stamenkovic A, Nikolic T, Stojanovic M, Scepanovic Lj, Hadzibegovic A, Obrenovic R, Vujosevic I, Stankovic S, Djuric M, Jakovljevic B, Djuric D. The effects of subchronic methionine overload administered alone or simultaneously with L-cysteine or N-acetyl-L-cysteine on body weight, homocysteine levels and biochemical parameters in the blood of male wistar rats. Ser J Exp Clin Res. 2016; 17(2): 1-1. DOI: 10.1515SJECR-2016-0017 (M52)

Rukovodilac laboratorije: Prof. dr Dejan Nešić
Oblast rada: Centralna dejstva regulatornih peptida na endokrini sistem, motorno ponašanje, metabolizam i energetsku homeostazu, Neuroendokrinologija

Kontakt telefon: 011-3607-101
Kontakt el. adresa: dejan.nesic@med.bg.ac.rs, drdejannesic@yahoo.com
Adresa: Višegradksa 26, 11 000 Beograd

Godina početka rada: 1986

Istraživači:

• Prof. dr Sanja Mazić
• Prof. dr Dejan Žikić
• Asisit. dr Biljana Đurić
• Asist. dr Nikola Topalović

Prethodni istraživači:

• Prof. dr Vesna Starčević, osnivač laboratorije
• Walter B. Severs, Department of Pharmacology, College of Medicine, Pennsylvania State University, Hershey, PA, USA
• Prof. dr Bosiljka Plećaš – Solerević, Institut za fiziologiju, Faramaceutski fakultet, Univerzitet u Beogradu
• Prof. dr Mirjana Šumarac – Dumanović, Institut za endokrinologiju, dijabetes i bolesti metabolizma, Klinički centar Srbije
• Doc. dr Saško Velkovski
• Doc. dr Darko Stevanović
• dr Verica Milošević, naučni savetnik, Institut za biološka istraživanja „Siniša Stanković“, Beograd
• 1980 – 1985: saradnik u međunarodnom istraživačkom projektu „Morfološke i eletrofiziološke studije mozga“, projekat finansiran od strane akademije nauka SSSR

Projekti:

• 2011 – do danas: Potprojekt: „Integrativni neuroendokrini procesi u očuvanju energetske homeostaze organizma“ deo Integrativnog projekta pod nazivom: „Modulacija signalnih puteva koji kontrolišu intracelularni energetski balans u terapiji tumora i neuro-imuno-endokrinih poremećaja“, (III 41025).
• 2006 – 2010: Projekt osnovnih istraživanja: Regulatorni peptidi u integrativnim procesima nervnog i endokrinog sistema (145003B).
• 2002 – 2005: Regulatorni peptidi u integrativnim procesima nervnog i endokrinog sistema (1385B).
• 1996 – 2002: Projekt osnovnih istraživanja: Regulatorni peptidi u integrativnim procesima nervnog sistema
• 1996 – 2000: Makroprojekt: Integrativne funkcije nervnog sistema,
• 1986 – 1996: Projekt osnovnih istraživanja: Neurohumoralni mehanizmi vaskularnihvaskularnih reakcija u CNS.

Radovi:

• Ristić N., Stevanović D., Nešić D., Ajdžanović V., Rakočević R., Jarić I., Milošević V. Diet induced obesity and ghrelin effects on pituitary gonadotropes: Immunohistomorphometric Study in Male Rats. Cell Journal (Yakhteh) 2016; 17 (4): 711-719.
• Nešić D., Stevanović D., Đelić M., Mazić S., Trbojević – Stanković J., Soldatović I., Stajić – Trošić J., Starčević V. The effects of centrally applied ghrelin on appetite and metabolic parameters during aging. Digest Journal of Nanomaterials and Biostructures 2014; 9 (4): 1439-1449.
• Milošević V., Ajdžanović V., Nešić D., Starčević V., Filipović B., Rakočević R., Stevanović D. Central ghrelin treatment stimulates ACTH cells in normal-fed, food-restricted and high-fed rats: immunohistomorphometric and hormonal study. Acta histochemica 2013; 115: 858-864.
• Nešić D., Stevanović D., Stanković S., Milošević V., Trajković V., Starčević V., Severs W. Age-dependent modulation of central ghrelin effects on food intake and lipid metabolism in rats. European Journal of Pharmacology 2013; 710 (1-3): 85-91.
• Nešić D., Stevanović D., Stanković S., Milošević V., Trajković V., Starčević V., Severs W. Age-dependent modulation of central ghrelin effects on food intake and lipid metabolism in rats. European Journal of Pharmacology 2013; 710 (1-3): 85-91.
• Pantić I., Nešić D., Stevanović D., Starčević V., Pantić S., Trajković V. Effects of ghrelin on structural complexity of exocrine pancreas tissue. Microscopy and Microanalysis 2013; 19 (3): 553-558.
• Plećaš – Solarević B., Nešić D., Stevanović D., Obradović A., Đelić M., Milošević V., Starčević V. Histomorphometric features of ventral prostate in different aged rats after central ghrelin treatment. General Physiology and Biophysics 2012; 31 (2): 203-210.
• Stevanović D., Starčević V., Vilimanovich U., Nešić D., Vučićević L., Misirkić M., Janjetović K., Savić E., Popadić D., Sudar E., Micić D., Šumarac-Dumanović M., Trajković V. Immunomodulatory actions of central ghrelin in diet-induced energy imbalance. Brain Behav Immun 2012; 26 (1): 150-158.
• Milošević V., Stevanović D., Nešić D., Šošić – Jurjević B., Ajdžanović V., Starčević V., Severs W. B. Central effects of ghrelin on adrenal cortex: a morphological and functional study. General Physiology and Biophysics 2010; 29: 194-202.
• Šošić – Jurjević B., Stevanović D., Milošević V., Sekulić M., Starčević V. Central Ghrelin Affects Pituitary – Thyroid Axis: Histomorphological and Hormonal Study in Rats. Neuroendocrinology 2009. 89: 327 – 336.
• Šumarac – Dumanović M., Stevanović D., Ljubić A., Jorga J., Simić M., Stamenković – Pejković D., Starčević V., Trajković V., Micić D. Increased activity of interleukin-23/interleukin-17 proinflammatory axis in obese women. Int J Obes (Lond). 2009; 33 (1): 151 – 156.
• Vučićević L., Misirkić M., Janjetović K., Harhaji – Trajković L., Prica M., Stevanović D., Isenović E., Sudar E, Šumarac – Dumanović M., Micić D., Trajković V. AMP – activated protein kinase – dependent and – independent mechanisms underlying in vitro antiglioma action of compound C. Biochem Pharmacol. 2009; 77 (11): 1684 – 1693.
• Perić – Mataruga V., Mirčić D., Vlahović M., Mrdaković M., Todorović D., Stevanović D., Milošević V.: Effects of ghrelin on the feeding behaviour of Lymantria dispar L. (Lymantriidae) caterpillars. Appetite 2009; 53 (1):147 – 150.
• Nešić D., Stevanović D., Ille T., Petričević S., Maširević – Drašković G., Starčević V. Centrally applied ghrelin affects feeding dynamics in male rats. Journal of Physiology and Pharmacology 2008; 59 (3): 489-500.
• Šošić – Jurjević B., Stevanović D., Milošević V., Sekulić M., Starčević V. Central Ghrelin Affects Pituitary – Thyroid Axis: Histomorphological and Hormonal Study in Rats. Neuroendocrinology 2009. 89: 327 – 336.
• Šumarac – Dumanović M., Stevanović D., Ljubić A., Jorga J., Simić M., Stamenković – Pejković D., Starčević V., Trajković V., Micić D. Increased activity of interleukin-23/interleukin-17 proinflammatory axis in obese women. Int J Obes (Lond). 2009 Jan; 33 (1): 151 – 156.
• Vučićević L., Misirkić M., Janjetović K., Harhaji – Trajković L., Prica M., Stevanović D., Isenović E., Sudar E, Šumarac – Dumanović M., Micić D., Trajković V. AMP – activated protein kinase – dependent and – independent mechanisms underlying in vitro antiglioma action of compound C. Biochem Pharmacol. 2009; 77 (11): 1684 – 1693.
• Šošić – Jurjević B., Stevanović D., Milošević V., Sekulić M., Starčević V. Central ghrelin affects pituitary – thyroid axis: histomorphological and hormonal study in rats. Neuroendocrinology 2009. 89: 327 – 336.
• Perić – Mataruga V., Mirčić D., Vlahović M., Mrdaković M., Todorović D., Stevanović D., Milošević V.: Effects of ghrelin on the feeding behaviour of Lymantria dispar L. (Lymantriidae) caterpillars. Appetite 2009; 53 (1):147 – 150.
• Stevanović D., Nešić D., Milošević V., Starčević V., Severs W. B. Consumatory behaviour and metabolic indicators after central ghrelin injections in rats. Regulatory Peptides 2008; 147 (1-3): 52-59.• Stevanović D., Milošević V., Starčević V., Severs W.B. The effect of centrally administered ghrelin on pituitary ACTH cells and circulating ACTH and corticosterone in rats. Life Scienece 2007; 80 (9): 867-872.
• Stojimirović B., Trbojević – Stanković J., Nešić D. Animals models in peritoneal dialysis. Scandinavian Journal of Laboratory Animal Science 2007; 34 (4): 283-289.
• Maširević – Drašković G., Terzić M., Nešić D., Stevanović D., Milošević V., Starčević V., Severs B. W. Effects of somatostatin -14 on active avoidance behavior in female rats. Archives of Biological Science, Belgrade 2007; 59 (4): 55-56.
• Nestorović N., Terzić M., Negić N., Starčević V., Milošević V.: Neonatalaly applied SRIH-14 has immediate and prolonged inhibitory effect on GH cells. Acta Veterinaria, 2006; 56(5-6):457-466.
• Trbojević J., Nešić D., Laušević Ž., Obradović M., Brajušković G., Stojimirović B. Histological characteristics of healthy animal peritoneum. Acta Veterinaria 2006; 56 (5-6): 405-412.
• Stevanović D., Milošević V., Nešić D., Ajdžanović V., Starčević V., Severs W. B. Central effects of ghrelin on serum growth hormone and morphology of pituitary somatotropes in rats. 2006; 231 (10): 1610-1615.
• Milošević V., Nestorović N., Filipović B., Velkovski S., Starčević V. Centrally applied somatostatin influences morphology of pituitary FSH cells but not FSH release. General Physiology and Biophysics 2004; 23 (3): 375-380.
• Đergović – Petrović D., Živković I., Rakin A., Kosec D., Dimitrijević Lj., Starčević V., Severs W., Mićić M. Somatostatin-14 alters the thymus size and relation among the thymocyte subpopulations in peripubertal rats. Neuropeptides 2004; 38: 25-34.
• Velkovski S., Mazić S., Nešić D., Igrački I., Milošević V., Starčević V. Increased platelet aggregability following an atherogenic diet in rabbits. Acta Veterinaria 2002; 52 (1): 11-18.• Starčević, V. , Milošević, V., Brkić, B., Severs W. B. Somatostatin affects morphology and secretion of pituitary luteinizing hormone (LH) cells in male rats. Life Sci 2002; 70: 3019-3027.
• Starčević V. , Milošević V., Brkić B., Severs W. B. Effects of centrally ap­plied somatostatin on pituitary adrenocorticotropes in female rats. Pharmacology 2000; 60: 203-207.
• Milošević V., Brkić B., Velkovski S. D., Sekulić M., Lovren M., Starčević V., Severs W. B. Morphometric and functional changes of the rat pituitary somatotropes and lactotropes after central ad­mi­ni­stra­tion of somatostatin. Pharmacology 1998; 57: 27-34.
• Milošević V., Velkovski S., Brkić B., Sekulić M., Lovren M., Sta­rče­vić V. , Severs W. B. Inhibitory effects of centrally administered so­ma­­tostatin on the adrenal zona glomerulosa in male rats. Pharmacology 1996;, 53: 369-375.
• Morrow B. A., Holt, M. R., Starčević V. P. , et all. Mechanism of delayed intracranial hypertension after cerebroventricular infusions in conscious rats. Brain. Res 1992;, 570: 218-224.
• Morrow B. A., Starčević V. P., Keil L. C., et all. Intracranial hypertension after cerebroventricular infusions in conscious rats. Am. J. Physiol. 1990; 258: R1170-R1176.
• Balaban C. D., Starčević V. P. , Severs W. B. Neuropeptide modulation of central vestibular circuits. Pharmacol. Rev. 1989; 41: 53-90.
• Starčević V. P. , Morrow B. A., Farner L. A., et all. Long-term recording of cerebrospinal fluid pressure in freely behaving rats. Brain. Res 1988; 462: 112-117.

STUDENTI MFUB koji su bili uključeni u rad Laboratorije za neuroendokrinologiju i metabolizam u program CSNIRS-a pod mentorstvom nekog od njenih članova (prikazano sumarno):

dr Milica Terzić, dr Ivan Tomić, dr Ana Munjiza, dr Jelna Potić, dr Sandra Aleksić, dr Rastko Rakočević; dr Joko Poleksić; dr Jasmin Popara; dr Saša Ilić, dr Stefan Repac, dr Andrija Jekić, dr Vladan Jarić, dr Bojan Petrović, dr Ivana Živković, dr Diana Radović, dr Dušan Milenković, dr Darko Radaković, dr Milan Mišković, dr Nikola Božović, dr Mirko Topalović, dr Luka Petrović, dr Stefan Ilić, dr Dragan Matić, dr Ivan Brkić, dr Aleksandra Božović, dr Branko Zvizdić, dr Hana Rajevac, dr Aleksandar Mitrović, dr Dane Miroslav Stošić

Rukovodilac laboratorije: Doc. dr Igor V. Pantić
Oblast rada: Molekularna medicina, biologija ćelije, analiza signala, nanomedicina

Kontakt telefon: +381 11 360 709 7
Kontakt el. adresa: igor.pantic@med.bg.ac.rs
Adresa: Višegradska 26/2, 11129, Beograd

Godina početka rada: 2013

Istraživači:

• Doc. dr Igor Pantić
• dr Dubravka Nikolovski
• dr Anita Milanović
• dr Draga Dimitrijević
• dr Milan Perović
• dr Jovana Paunović Pantić
• dr Miloš Basailović
• dr Marta Jeremić
• dr Danica Petrović
• dr Jelena Čumić
• dr Anita Petković Karić
• dr Uroš Karić
• Prof. dr Siniša Ristić
• dr Claude Brodski
• dr Yunus Balcik
• David Šarenac
• Esma Kadrić

Projekti:

• III 41027 (2011-  ) Ćelijske i molekulske osnove malignih i kardiovaskularnih oboljenja
• OI 175059 (2011 –  ) Optičko mikroskopska, imunomorfološka, molekularno-biološka i genetska ispitivanja malignih i nemalignih bolesti bubrega
• Erasmus+ project “Advanced Data Analysis”, Erasmus+ Key Action 2 – Capacity building in the field of higher education, European Union

Odabrani radovi:

• Nikolovski D, Cumic J, Pantic Application of Gray Level co-Occurrence Matrix Algorithm for Detection of Discrete Structural Changes in Cell Nuclei After Exposure to Iron Oxide Nanoparticles and 6-Hydroxydopamine. Microsc
  Microanal. 2019 Aug;25(4):982-988.
• Paunovic J, Vucevic D, Radosavljevic T, PanticS, Veskovic M, Pantic  Gray-level co-occurrence matrix analysis of chromatin architecture in periportal and perivenous hepatocytes. Histochem Cell Biol.  2019 Jan;151(1):75-83.
• PanticI, Sarenac D, Cetkovic M, Milisavljevic M, Rakocevic R, Kasas S. Silver nanomaterials in contemporary molecular physiology research. Curr Med Chem. 2019;26:1-11. doi: 10.2174/0929867325666180719110432.
• Martinovic T, Ciric D, Pantic I, Lalic K, Rasulic I, Despotovic S, Lalic I, Djuricic D, Bumbasirevic V, Kravic-Stevovic T. Unusual shape and structure of lymphocyte nuclei is linked to hyperglycemia in type 2 diabetes patients. Tissue Cell. 2018 Jun;52:92-100.
• Nikolovski D, Jeremic M, Paunovic J, Vucevic D, Radosavljevic T, Radojevic-Skodric S, Rakocevic R, Pantic Application of iron oxide nanoparticles in contemporary experimental physiology and cell biology research. Rev Adv Mater Sci. 2018;53:74-78.
• Paunovic J, Vucevic D, Radosavljevic T, PanticS, Nikolovski D, Pantic Effects of metallic nanoparticles on physiological liver functions. Rev Adv Mater Sci. 2017;49:123-128.
• Nikolovski D, Dugalic S, Pantic Iron oxide nanoparticles decrease nuclear fractal dimension of buccal epithelial cells in a time-dependent manner. J Microsc. 2017 Oct;268(1):45-52.
• PanticI, Paunovic J, Vucevic D, Radosavljevic T, Dugalic S, Petkovic A, Radojevic-Skodric S, Pantic Postnatal Developmental Changes in Fractal Complexity of Giemsa-Stained Chromatin in Mice Spleen Follicular Cells. Microsc Microanal. 2017 Oct;23(5):1024-1029.
• Dimitrijevic N, Pantic Advanced materials in oral physiology and pathophysiology research. Rev Adv Mater Sci. 2016;44:297-301.
• PanticI, Petrovic D, Nesic D, Markovic L, Petkovic A, Pantic Application of graphene in experimental physiology research. Rev Adv Mater Sci. 2016;46(1):1-5.
• PanticI, Nesic Z, Paunovic J, Radojevic-Skodric S, Cetkovic M, Basta Jovanovic G. Fractal analysis and Gray level co-occurrence matrix method for evaluation of reperfusion injury in kidney medulla. J Theor Biol. 2016 May 21;397:61-7.
• PanticI, Nesic D, Basailovic M, Cetkovic M, Mazic S, Suzic-Lazic J, Popevic M. Chromatin Fractal Organization, Textural Patterns, and Circularity of Nuclear Envelope in Adrenal Zona Fasciculata Cells. Microsc Microanal. 2016 Dec;22(6):1120-1127.
• PanticI, Petrovic D, Paunovic J, Vucevic D, Radosavljevic T, Pantic Age-related reduction of chromatin fractal dimension in toluidine blue – stained hepatocytes. Mech Ageing Dev. 2016 Jul;157:30-4.
• PanticI, Dimitrijevic D, Nesic D, Petrovic D. Gray level co-occurrence matrix algorithm as pattern recognition biosensor for oxidopamine-induced changes in lymphocyte chromatin architecture. J Theor Biol. 2016 Oct 7;406:124-8.
• PanticI, Paunovic J, Dimitrijevic I, Blachnio A, Przepiorka A, Pantic Novel strategies for neurotransmitter detection and measurement using advanced materials. Rev Adv Mater Sci. 2015;42(1):1-5.
• Perovic M, Gojnic M, Arsic B, PanticI, Stefanovic T, Kovacevic G, Kovacevic M, Garalejic E, Dugalic S, Radakovic J, Babic U, Isenovic ER. Relationship between mid-trimester ultrasound fetal liver length measurements and gestational diabetes mellitus. J Diabetes. 2015 Jul;7(4):497-505.
• PanticI, Paunovic J, Dimitrijevic I, Pantic Gold nanomaterials in contemporary neurophysiology, neurology and psychiatry research. Rev Adv Mater Sci. 2015;40:257-261.
• Lavrnja I, Parabucki A, Brkic P, Jovanovic T, Dacic S, Savic D, PanticI, Stojiljkovic M, Pekovic S. Repetitive hyperbaric oxygenation attenuates reactive astrogliosis and suppresses expression of inflammatory mediators in the rat model of brain injury. Mediators of Inflammation. 2015;2015:4405.
• PanticI, Basailovic M, Paunovic J, Pantic Relationship between chromatin complexity and nuclear envelope circularity in hippocampal pyramidal neurons. Chaos, Solitons & Fractals. 2015;76:271–277.
• PanticI, Dacic S, Brkic P, Lavrnja I, Jovanovic T, Pantic S, Pekovic S.Discriminatory ability of fractal and grey level co-occurrence matrix methods in structural analysis of hippocampus layers. J Theor Biol. 2015;370:151-156.
• PanticI, Dacic S, Brkic P, Lavrnja I, Pantic S, Jovanovic T, Pekovic S. Application of fractal and grey level co-occurrence matrix analysis in evaluation of brain corpus callosum and cingulum architecture. Microsc Microanal. 2014 Oct;20(5):1373-81.
• Dimitrijevic I, Pantic Application of nanoparticles in psychophysiology and psychiatry research. Rev Adv Mater Sci. 2014;38(1):1-6.
• Pantic Application of silver nanoparticles in experimental physiology and clinical medicine: current status and future prospects. Rev Adv Mater Sci. 2014;37:15-19
• PanticI, Paunovic J, Basta-Jovanovic G, Perovic M, Pantic S, Milosevic NT. Age-related reduction of structural complexity in spleen hematopoietic tissue architecture in mice. Exp Gerontol. 2013 Sep;48(9):926-32
• PanticI, Paunovic J, Perovic M, Cattani, C, Pantic S, Suzic S, Nesic D, Basta-Jovanovic G. Time-dependent reduction of structural complexity of the buccal epithelial cell nuclei after treatment with silver nanoparticles. J Microsc. 2013 Dec;252(3):286-94.
• PanticI, Basta-Jovanovic G, Starcevic V, Paunovic J, Suzic S, Kojic Z, Pantic Complexity reduction of chromatin architecture in macula densa cells during mouse postnatal development. Nephrology. 2013 Feb;18(2):117-124.
• PanticI, Pantic S, Paunovic J, Perovic M. Nuclear entropy, angular second moment, variance and texture correlation of thymus cortical and medullar lymphocytes: Grey level co-occurrence matrix analysis An Acad Bras Cienc. 2013;85(3):1063-1072

Rukovodilac laboratorije: Prof dr Olivera Stanojlović
Oblast rada: neurofiziologija, neuroendokrinologija

Kontakt telefon: +381 11 36 07 106
Kontakt el. adresa: olivera.stanojlovic@med.bg.ac.rs, solja@afrodita.rcub.bg.ac.rs
Adresa: Višegradska 26/II, 11000 Beograd

Godina početka rada: 1970.

Istraživači:

• Prof dr Olivera Stanojlović
• Prof dr Aleksandra Rašić-Marković
• Doc dr Dragan Hrnčič
• Doc dr Dušan Mladenović
• Dr Nikola Šutulović, saradnik u nastavi

Prethodni istraživači:

• Akademik Veselinka Šušić, osnivač Laboratorije
• Prof dr Ružica Kovačević
• Prof dr Gordana Maširević-Drašković
• Doc dr Dragana Živanović

Doktorandi:

• Dr Bojana Rankov Petrović
• Dr Nikola Šutulović
• Dr Marko Vorkapić
• Dr Željko Grubač
• Dr Anida Ademović
• Dr Emilija Djurić
• Dr Dolika Vasović
• Dr Danijel Škrijelj

Projekti:

• 2002 – sada Projekat „Razvoj animalnih modela epilepsija i testiranje konvulzivnih i antikonvulzivnih supstanci“. Broj projekta: 1415B (2002-2006); 145029B (2006-2010); 175032 (2011-sada). Rukovodilac projekta: Prof.dr Olivera Stanojlović.
• 1990 – 2018. Projekat „Eksperimentalna i klinička istraživanja bioloških aktivnih supstanci (konvulzanti, antikonvulzanti, peptid spavanja i njegovi analozi) na ekscitabilnost centralnog nervnog sistema“. Rukovodilac: Akademik prof. dr Veselinka Šušić.
• 2011 – 2014. EU COST Akcija 1005 European Network on Gasotransmitters

Radovi:

• Grubac Z, Sutulovic N, Ademovic A, Velimirovic M, Rasic-Markovic A, Macut D, Petronijevic N, Stanojlovic O, Hrncic D. Short-term sleep fragmentation enhances anxiety-related behavior: The role of hormonal alterations.PLoS One. 2019 Jul 3;14(7).
• Šutulović N, Grubač Ž, Šuvakov S, Jovanović Đ, Puškaš N, Macut Đ, Marković AR, Simić T, Stanojlović O, Hrnčić D. Chronic prostatitis/chronic pelvic pain syndrome increases susceptibility to seizures in rats and alters brain levels of IL-1β and IL-6.Epilepsy Res. 2019; 153:19-27.
• Mladenović D, Radosavljević T, Hrnčić D, Rasic-Markovic A, Stanojlović O. The Effects od dietary methionine restriction on the function and metabolic reprogramming in the liver and brain – implication for longevity. Rev. Neurosci. 2019. Jul 26;30(6):581-593
• Rankov-Petrovic B, Mladenovic D, Simic T, Suvakov S, Jovanovic Dj, Puskas N, Zaletel I, Velimirovic M, Cirkovic V, Macut Dj, Stanojlovic O, Hrncic D, Rasic-Markovic A. Prenatal Androgenization Induces Anxiety-Like Behavior in Female Rats, Associated with Reduction of Inhibitory. Interneurons and Increased BDNF in Hippocampus and Cortex . Biomed Res Int. 2019 Jun, 10; 2019:3426092
• Đurić E, Hrnčić D, Šutulović N, Škrijelj D, Grubač Ž, Ćirković V, Rašić-Marković A, Stanojlović O. Folic acid supplementation alleviates behavioral manifestations of lindane-induced seizures. Arch Biol Sci 2019; in press.
• Plavsic L, Knezevic OM, Sovtic A, Minic P, Vukovic R, Mazibrada I, Stanojlovic O, Hrncic D, Rasic-Markovic A, Macut D. Effects of high-intensity interval training and nutrition advice on cardiometabolic markers and aerobic fitness in adolescent girls with obesity. Appl Physiol Nutr Metab. 2019 Aug 6. doi: 10.1139/apnm-2019-0137.
• Stevanovic D, Bozic-Antic I, Stanojlovic O, Vojnovic Milutinovic D, Bjekic-Macut J, Jancic J, Macut D. Health-related quality of life questionnaire for polycystic ovary syndrome (PCOSQ-50): a psychometric study with the Serbian version. Women Health. 2019 Mar 14:1-11.
• Macut D, Mladenović V, Bjekić-Macut J, Livadas S, Stanojlović O, Hrnčić D, Rašić-Marković A, Milutinović DV, Andrić Z. Hypertension in polycystic ovary syndrome: Novel insights. Curr Hypertens Rev. 2019 May 30. doi: 10.2174/157340211566619053107142275
• Macut D, Bjekić-Macut J, Livadas S, Stanojlović O, Hrnčić D, Rašić-Marković A, Milutinović DV, Mladenović V, Andrić Z. Nonalcoholic Fatty Liver Disease in Patients with Polycystic Ovary Syndrome. Curr Pharm Des. 2018;24(38):4593-4597
• Macut D, Milutinović DV, Rašić-Marković A, Nestorov J, Bjekić-Macut J, Stanojlović O. Decade in female reproduction: an endocrine view on the past and into future. Hormones (Athens) 2018, 17(4):497-505. Review.
• Hrnčić D, Šutulović N, Grubač Ž, Rašić- Marković A, Stanojlović O.. The central nervous system is not imunoprivileged: inflammation and epileptogenesis. Vojnosanit Pregl 2018, 75 (8):820-825.
•  Hrnčić D, Grubač Ž, Šutulović N, Rašić-Marković A, Ademović A, Stanojlović O. Modulatory effects of delta sleep-inducing peptide in a lindane model of generalized seizures. Arch Biol Sci. 2018;70(3):559-566
• Hrncic D, Rasic-Markovic A, Macut D, Mladenovic D, Susic V, Djuric D, Stanojlovic O. Sulfur – Containing Amino Acids Homocysteine And Taurine In Seizures: Current State Of The Art. Curr Med Chem. 2018, 30;25(3):378-390.
• Milovanovic P, Hrncic D, Radotic K, Stankovic M, Mutavdzic D, Djonic D, Rasic-Markovic A, Djuric D,Stanojlovic O, Djuric M. Moderate hyperhomocysteinemia induced by short-term dietary methionine overload alters bone microarchitecture and collagen features during growth. Life Sci. Dec 15;191:9-16. 2017
• Hrnčić D, Grubač Ž, Rašić-Marković A, Šutulović N, Šušić V, Bjekić-Macut J, Stanojlović O. Sleep disruption increases seizure susceptibility: Behavioral and EEG evaluation of an experimental model of sleep apnea. Physiol Behav. 2016 Mar 1;155:188-94
• Mladenović D, Hrnčić D, Rašić-Marković A, Macut Dj, Stanojlović O.The Influence of Finasteride on Mean and Relative Spectral Density of EEG Bands in Rat Model of Thioacetamide-Induced Hepatic Encephalopathy.Neurotox Res. 2016, 30(2):150-8.
• Reitz MC, Hrncic D, Treede RD, Caspani O. A comparative behavioural study of mechanical hypersensitivity in 2 pain models in rats and humans. Pain. 2016;157(6):1248-58. doi: 10.1097/j.pain.0000000000000515. (IF 5,557, M21a).
• Hrncic D, Mikić J, Rasic-Markovic A, Velimirović M, Stojković T, Obrenović R, Rankov-Petrović B, Šušić V, Djuric D, Petronijević N, Stanojlovic O. Anxiety-related behavior in hyperhomocysteinemia induced by methionine nutritional overload in rats: role of the brain oxidative stress.Can J Physiol Pharmacol. 2016, 30:1-9
• Rasic-Markovic A, Hrncic D, Krstic D, Colovic M, Djuric E, Rankov-Petrovic B, Susic V, Stanojlovic O, Djuric D. The effect of subchronic supplementation with folic acid and l-arginine on homocysteine-induced seizures. Can J Physiol Pharmacol. 2016 Jun 22:1-7
• Olivera Stanojlović, Dragan Hrnčić, Aleksandra Rašić – Marković, Duško Kornjača, Dušan Mladenović3 and Dragan M. Djurić. The Acute Effects Of Vibroacoustically-Induced Microvibrations On EEG Activity In Rats. International Journal of Engineering And Science 2016, 6, (8) 07-11.
• Božić-Antić I, Ilić D, Bjekić-Macut J, Bogavac T, Vojnović Milutinović D, Kastratović-Kotlica B, Milić N, Stanojlović O, Andrić Z, Macut D. Lipid accmulation product as a marker of cardiometabolic susceptability in women with different phenotypes of polycystic ovary syndrome. Eur J Endocrinol. 2016. 15:16-0775.
• Bjekić-Macut J, Radosavljević V, Andrić Z, Ilić D, Stanojlović O, Milutinović DV, Antić IB, Zdravković M, Hinić S, Macut D, Žarković M. Cortisol Response to Low-dose (1 µg) ACTH Stimulation for the Prediction of Outcome in Patients with Systemic Inflammatory Response Syndrome. J Med Biochem. 2016 Nov 2;35(4):428-435.
• Mladenović D, Petronijević N, Stojković T, Velimirović M, Jevtić G, Hrnčić D, Radosavljević T, Rašić-Marković A, Maksić N, Djuric D, Stanojlović O. Finasteride Has Regionally Different Effects on Brain Oxidative Stress and Acetylcholinesterase Activity in Acute Thioacetamide-Induced Hepatic Encephalopathy in Rats. PLoS One. 2015 Aug 4;10(8)
• Rasic-Markovic A, Rankov-Petrovic B, Hrncic D, Krstic D, Colovic M, Macut Dj, Djuric D, Stanojlovic O The effect of subchronic supplementation with folic acid on homocysteine induced seizures. Acta Physiol Hung. 2015; 102(2):
• Macut D, Božić Antić I, Bjekić-Macut J, Panidis D, Tziomalos K, Vojnović Milutinović D, Stanojlović O, Kastratović-Kotlica B, Petakov M, Milić N. Lipid accumulation product is associated with metabolic syndrome in women with polycystic ovary syndrome. Hormones (Athens). 2015 15
• Srejovic I, Jakovljevic V, Zivkovic V, Barudzic N, Radovanovic A, Stanojlovic O, Djuric DM. The effects of the modulation of NMDA receptors by homocysteine thiolactone and dizocilpine on cardiodynamics and oxidative stress in isolated rat heart. Mol Cell Biochem.; 401(1-2):97-105, 2015.
• Macut D, Bačević M, Božić-Antić I, Bjekić-Macut J, Čivčić M, Erceg S, Vojnović Milutinović D, Stanojlović O, Andrić Z, Kastratović-Kotlica B, Šukilović T. Predictors of subclinical cardiovascular disease in women with polycystic ovary syndrome: interrelationship of dyslipidemia and arterial blood pressure. Int J Endocrinol. 2015: 1-9, 2015.
• Stojanovic M, Scepanovic Lj, Hrncic D, Rasic-Markovic A, Djuric D, Stanojlovic O. Multidisciplinary approach to nitric oxide signaling: Focus on gastrointestinal and central nervous system. Vojnosanitetski pregled. Military-medical and pharmaceutical review 2015;72(7):619-24.
• Hrnčić D, Rašić-Marković A, Macut D, Šušić V, Djuric D, Stanojlović O. Homocysteine thiolactone-induced seizures in adult rats are aggravated by inhibition of inducible nitric oxide synthase. Hum Exp Toxicol. 2014, 33(5):496-503
• Hrncic D, Rasic-Markovic A, Lekovic J, Krstic D, Colovic M, Macut D, Susic V, Djuric D, Stanojlovic O. Exercise decreases susceptibility to homocysteine seizures: the role of oxidative stress. Int J Sports Med. 2014, 35(7):544-50.
• Hrnčić D, Rašić-Marković A, Stojković T, Velimirović M, Puškaš N, Obrenović R, Macut D, Sušić V, Jakovljević V, Djuric D, Petronijević N, Stanojlović O. Hyperhomocysteinemia induced by methionine dietary nutritional overload modulates acetylcholinesterase activity in the rat brain. Mol Cell Biochem 396( 1-2): 99-105, 2014
• Mladenovic D, Hrncic D, Petronijevic N, Jevtic G, Radosavljevic T, Rasic-Markovic A, Puskas N, Maksic N, Stanojlovic O. Finasteride improves motor, EEG and cellular changes in rat brain in thioacetamide-induced hepatic encephalopathy. Am J Physiol Gastrointest Liver Physiol 307(9):G931-40, 2014
• Radunovic N, Lockwood CJ, Stanojlovic O, Steric M, Kontic-Vucinic O, Sulovic N, Hrncic D, Ackerman Iv WE. Fetal and maternal plasma homocysteine levels during the second half of uncomplicated pregnancy. J Matern Fetal Neonatal Med 27:1-6, 2014.
• Stanojlović O, Nikolić T, Hrnčić D, Radonjić N, Rašić-Marković A, Mladenović D, Petronijević N. Ontogenetic influence on rat susceptibility to lindane seizure after pretreatment with phencyclidine. Environ Toxicol Pharmacol. 2013, 35(2):161-70.\
• Mladenovic D, Hrncic D, Rasic-Markovic A, Puskas N, Petrovich S, Stanojlovic O. Spectral analysis of thioacetamide-induced electroencephalographic changes in rats. Hum Exp Toxicol. 2013, 32(1):90-100.
• Hrncić D, Rasić-Marković A, Bjekić-Macut J, Susić V, Djuric D, Stanojlović O. Paradoxical sleep deprivation potentiates epilepsy induced by homocysteine thiolactone in adult rats. Exp Biol Med (Maywood). 2013, 238(1):77-83.
• Mladenović D, Ninković M, Aleksić V, Šljivančanin T, Vučević D, Todorović V, Stanković M, Stanojlović O, Radosavljević T. The effect of calorie restriction on acute ethanol-induced oxidative and nitrosative liver injury in rats. Environ Toxicol Pharmacol. 2013, 36(2):296-302.
• Mladenović D, Krstić D, Colović M, Radosavljević T, Rasić-Marković A, Hrncić D, Macut D, Stanojlović O. Different sensitivity of various brain structures to thioacetamide-induced lipid peroxidation. Med Chem. 2012, 8(1):52-8.
• Hrncić D, Rasić-Marković A, Krstić D, Macut D, Susić V, Djuric D, Stanojlović O. Inhibition of the neuronal nitric oxide synthase potentiates homocysteine thiolactone-induced seizures in adult rats. Med Chem. 2012, 8(1):59-64.
• Hrnčić D, Rašić-Marković A, Bjekić-Macut J, Šušić V, Mladenović D, Djurić D, Stanojlović O. Geseous neurotransmitter nitric oxide: its role in experimental models of epilepsy. Archives of Biological Sciences 2012; 64(3):1207-16. (IF 0,791; M23)
• Mladenović D, Hrnčić D, Rašić-Marković A, Puškaš N, Petrovich S, Stanojlović O. Bihaviour and electroencephalographic manifestations of thioacetamide-induced encephalopathy: possible mechanisms of neurotoxic effects. Archives of Biological Sciences, 2012; 64(3):829-41(IF 0,791; M23)
• Mladenović D, Radosavljević T, Hrnčić D, Rašić-Marković A, Puškaš N, Maksić N, Djuric D, Stanojlović O. Behavioral and electroencephalographic manifestations of thioacetamide-induced encephalopathy in rats. Can J Physiol Pharmacol. 2012, 90(9):1219-27.
• Hrnčić D, Rašić-Marković A, Djuric D, Šušić V, Stanojlović O. The role of nitric oxide in convulsions induced by lindane in rats. Food Chem. Toxicol. 2011;49 :947-54.
• Marković AR, Hrnčić D, Macut D, Stanojlović O, Djuric D Anticonvulsive effect of folic acid in homocysteine thiolactone-induced seizures. Cell Mol Neurobiol. 2011, 31(8):1221-8.
• Rašić-Marković A, Hrnčić D, Djurić D, Macut D, Lončar-Stevanović H, Stanojlović O. The effect of N-methyl-D-aspartate receptor antagonists on D,L-homocysteine thiolactone induced seizures in adult rats. Acta Physiol. Hung., 2011;98 :17-26.
• Hrnčić D, Rašić-Marković A, Krstić D, Macut D, Djuric D, Stanojlović O. The Role of Nitric Oxide in Homocysteine Thiolactone-Induced Seizures in Adult Rats. Cell. Mol. Neurobiol., 2010; 30: 219-31.
• Radosavljević T, Mladenović D, Jakovljević V, Vučević D, Rašić – Marković A, Hrnčić D, Djurić D, Stanojlović O. Oxidative stress in liver and red blood cells in acute lindane toxicity in rats. Human. Exp. Toxicol., 2009; 28:747-57.
• Macut D, Vojnović Milutinović D, Božić I, Matić G, Brkljačić J, Panidis D, Petakov M, Spanos N, Bjekić J, Stanojlović O, Milinković AP, Radojičić Z, Damjanović S. Age, body mass index, and serum level of DHEA-S can predict glucocorticoid receptor function in women with polycystic ovary syndrome. Endocrine 2010;37: 129-34.
• Mladenović D, Djuric D, Petronijević N, Radosavljević T, Radonjić N, Matić D, Hrnčić D, Rašić-Marković A, Vučević D, Dekanski D, Stanojlović O. The correlation between lipid peroxidation in different brain regions and the severity of lindane-induced seizures in rats. Mol. Cell. Biochem., 2010; 333:243-50.
• Hrnčić D, Rašić-Marković A, Sušić V, Djurić D, Stanojlović O. Influence of NR2B-Selective NMDA Antagonist on Lindane-Induced Seizures in Rats. Pharmacology 2009; 84:234-239.
• Rašić-Marković A, Djuric D, Hrnčić D, Lončar-Stevanović H, Vučević D, Mladenović D, Brkic P, Macut Dj, Stanojevic I, Stanojlović O. High dose of ethanol decreases total spectral power density in seizures induced by D,L – homocysteine thiolactone in adult rats. Gen. Physiol. Biophys., 2009; 28:25-3.
• Vučević D, Petronijević N, Radonjić N, Rašić-Marković A, Mladenović D, Radosavljević T, Hrnčić D, Djuric D, Sušić V, Macut Dj, Stanojlović O. Acetylcholinesterase as a potential target of acute neurotoxic effects of lindane in rats. Gen. Physiol. Biophys., 2009; 28:18-24.
• Stanojlović O, Rašić – Marković A, Hrnčić D, Šušić V, Macut Dj, Radosavljević T, Djurić D. Two types of seizures in homocysteine thiolactone – treated adult rats, behavioral and encephalographic study. Cell. Mol. Neurobiol. 2009; 29:329-39.
• Rasić-Marković A, Stanojlović O, Hrncić D, Krstić D, Colović M, Susić V, Radosavljević T, Djuric D.The activity of erythrocyte and brain Na+/K+ and Mg2+-ATPases in rats subjected to acute homocysteine and homocysteine thiolactone administration.Mol. Cell. Biochem. 2009; 327:39-45.
• Stanojlović O, Petrović B, Hrnčić D, Mladenović D, Rašić A, Šušić V. Effects of ethanol on electroencephalographic and behavioral sings of metaphit-inducted audiogenic seizure Acta Veterinaria (Beograd) 2008 ; 58:111-120.
• Radosavljević T, Mladenović D, Vučević D, Petrović J, Hrnčić D, Djurić D, Lončar – Stevanović H, Šušić V, Stanojlović O. Effect of acute lindane and alcohol intoxication on serum concentration of enzymes and fatty acids in rats. Food and Chemical Toxicology 2008, 46(5):1739-1743.
• Macut D, Panidis D, Glisić B, Spanos N, Petakov M, Bjekić J, Stanojlović O, Rousso D, Kourtis A, Bozić I, Damjanović S. Lipid and lipoprotein profile in women with polycystic ovary syndrome. Can. J. Physiol. Pharmacol., 2008; 86:199-204.
• Vučević D, Hrnčić D, Radosavljević T, Mladenović D, Đurić D, Rašić- Marković A, Lončar-Stevanović H, Macut Dj. Šušić V, Stanojlović O. Correlation between electroencephalographic and motor phenomena in lindane – induced experimental epilepsy in rats. Canad. Physiol. Pharmacol., 2008; 86:173-179.
• Mladenović D, Hrnčić D, Vučević D, Radosavljević T, Lončar – Stevanović H, Petrović J, Šušić V, Djurić D, Stanojlović O. Ethanol suppresed seizures in lindane- treated rats. Electroencephalographic and behavioral studies. J. Physiol. Pharmacol., 2007; 58:641-654.
• Mladenović D, Hrnčić D, Vučević D, Rašić- Marković A, Radosavljević T, Đurić D, Macut Dj, Šušić V, Šćepanović Lj, Stanojlović O. Dose – dependent effects of etanol on lindane – induced seizures. Can. J. Physiol. Pharmacol., 2008; 86:148-152.
• Rašić- Marković A, Krstić D, Vujović Z, Jakovljević V, Stanojlović O, Hrnčić D, Djurić D, Lončar – Stevanović H. Modulations of rabbit erythrocyte ATPase activities induced by in vitro and in vivo exposure to ethanol. Mol. Cell. Biochem., 2008; 308:111-116.
• Hrnčić D, Vučević D, Rašić A, Radosavljević T, Mladenović D, Šušić V, Djurić D, Stanojlović O. Moderate body hypothermia alleviates behavioral and EEG manifestations of audiogenic seizures in metaphit – treated rats. Canad J Physiol. Pharmacol., 2007; 85:1032-1037.
• Stanojlović O, Hrnčić D, Rašić A, Lončar–Stevanović H, Djurić D, Šušić V. Interaction of delta – sleep inducing peptide and valproate on metaphit audiogenic seizure model in rats. Cell. Mol. Neurobiology, 2007; 27 :923- 932.
• Stanojlović O, Hrnčić D, Živanović D, Šušić V. Anticonvulsant, but not antiepileptic action of valproate on audiogenic seizure in metaphit – treated rats. Clinical. Exp. Pharmacol. Physiol., 2007; 34:1010-1015.
• Stanojlović O, Hrnčić D, Rašić A, Šušić V, Živanović D. Beneficial effects of delta sleep inducing peptide on metaphit seizures. Acta Veterinaria (Beograd) 2007; 57:89-101.
• Hrnčić D, Stanojlović O, Živanović D, Šušić V. Delta-Sleep-Inducing Peptide Potentiates Anticonvulsive Activity of Valproate against Metaphit-Provoked Audiogenic Seizure in Rats. Pharmacology, 2006; 77:78-84.
• Stanojlović O, Hrnčić D, Živanović D, Šušić V i Aranđelović A. Does valproate act as an anticonvulsant or antiepileptic on metaphit –induced seizure in rats? Acta Veterinaria 2006; 56: 81-89.
• Stanojlović OP, Živanović DP, Mirković SD., and Mikhaleva II. Antiepileptic activity of delta sleep inducing peptide and its analogue in metaphit-provoked seizures in rats. Seizures, 2005;14: 240-247.
• Živanović D, Stanojlović O, Slobodan Mirković, Veselinka Šušić. Ontogenic study of metaphit-induced audiogenic seizures in rats. Devel. Brain Res., 2005; 155: 42-48.
• Živanović D, Stanojlović O, Veselinka Šušić, Jelena Stojanovic. The effects of phenytoin and phenobarbital on seizures induced by imipenem/cilastatin in rats. Acta Neurol. Belg., 2004; 104:20-26.
• Živanović D, Stanojlović O, Veselinka Šušić. Effect of manipulation of N-mrthyl-D-aspartate receptors on imipenem/cilastatin induced seizure in rats. Indian J. Med. Res., 2004; 119:79-85.
• Živanović D, Stanojlović O, Stojanovic J, Šušić V. Induction of audiogenic seizure in Imipenem\cilastatin-treatrd rats. Epilepsy&Behav 2004; 5: 151-158.
• Stanojlović O, Živanovic D, Mirkovic S. and Mikhaleva II. Delta Sleep-Inducing Peptide and its tetrapeptide analogue alleviate severity of metaphit seizures. Pharmacol. Biochem. Behav., 2004; 77:227-234.
• Stanojlović O, Živanović D. and Šušić V. The effects of delta sleep-inducing peptide on incidence and severity in metaphit-induced epilepsy in rats. Pharmacol. Res., 2002; 45:241-247.
• Stanojlović O, Živanović D. and Šušić V. N-methyl-D-aspartic acid-and metaphit-induced audiogenic seizures in rat model of seizure. Pharmacol. Res., 2000; 42:247-253.
• Živanović D, Šušić V. and Stanojlović O. CPP blocks sound-induced seizures in metaphit-treatrd rats. Med. Sci. Res., 1999; 27701-703.
• Živanović D, Šušić V. and Stanojlović O. Inhibition of metaphit-induced audiogenic seizure by APV in rats. Physiol. Res., 1999; 48:149-156.
• Živanović D, Šušić V. and Stanojlović O. The anticonvulsant potency of (±)-2 aminophosphonoheptanoic acid and (±)-2amino-5-phosphonovaleric acid against metaphit-induced audiogenic seizures in rats. Pharmacol. Res., 1998; 38:347-352.
• Živanović D, Šušić V. and Stanojlović O. APH, an NMDA receptor antagonist, blocks the metaphit-induced audiogenic seizures in rats. J. Physiol. (Paris), 1997; 91: 317-323.
• Šušić V, Marković O. Potentiation of Metaphit-Induced Audiogenic Seizures by REM Sleep Deprivation in Rats. Physiol. Behav., 1993; 53:1013-1020.
• Šušić VT, Marković O, Lipovac MN. Metaphit-Induced Audiogenic Seizure and Its Inhibition by MK-801: Electroencephalographic and Behavioral Characterization. Epilepsia, 1993; 34: 8-17.
•  Obal F, Kacsoh B, Alfoldi P, Payne L, Marković O, Grosvenor C, Krueger JM. Antiserum to Prolactin Decreases Rapid Eye Movement Sleep (REM Sleep) in the Male Rat. Physiol. Behav., 1992; 52: 1063-1068.

Odabrane publikacije iz ranijeg perioda laboratorije:

• Micić D, Karadzić V, Rakic LM. Changes of gamma-aminobutyric acid, glutamic acid and aspartic acid in various brain structures of cats deprived of paradoxical sleep. Nature. 1967;215(5097):169-70.
• Susić VT, Kovacević RM. Sleep patterns in the owl Strix aluco. Physiol Behav. 1973;11(3):313-7.
• Susić V, Kovacević R. Sleep patterns in chronic split-brain cats. Brain Res. 1974;65(3):427-41.
• Djuricić B, Masirević G, Susić V. Paradoxical sleep deprivation: effects on brain energy metabolism. Arch Int Physiol Biochim. 1977;85(2):213-9.
• Susić V, Masirević G. Effects of dihydroergotoxine (Redergine) on the sleep-wakefulness cycle in the cat. Gerontology. 1979;25(4):212-8.
• Susić V, Masirević G, Totić S. The effects of delta-sleep-inducing peptide (DSIP) on wakefulness and sleep patterns in the cat. Brain Res. 1987 Jun;414(2):262-70.
• Kostić VS, Susić V, Covicković-Sternić N, Marinković Z, Janković S. Reduced rapid eye movement sleep latency in patients with Parkinson’s disease. J Neurol. 1989; 236(7):421-3.

STUDENTI MFUB koji su bili uključeni u rad Laboratorije za neurofiziologiju u program CSNIRS-a pod mentorstvom nekog od njenih članova (prikazano sumarno):

Dr Dušan Ružičić, Dr Stevan Đurđević, Dr Vladimir Đurić, Dr Jelena Leković, Dr Jelena Mikić, Dr Vesna Lukić, Dr Katarina Nikolić, Dr Nikola Šutulović, Dr Željko Grubač, Dr Ajsela Huric, Dr Matija Miljević, Dr Đorđe Đorović, Dr Marko Vorkapić, Dr Željko Jovandić, Dr Maja Drašković, Dr Anida Ademović, Dr Danijel Škrijelj, Dr Emilija Djurić, Dr Aleksija Herrera, Dr Filip Milanović, Dr Nemanja Useinović, Dr Đorđe Kralj, Dr Aleksa Korugić, Dr Maja Velinović, Dr Dragana Teovanović, Božo Knežević, Aleksa Leković, Vanja Radišić, Ana Petronijević, Maja Macura, Đorđe Vukmirović, Aleksa Zubelić, Marina Sikiraš, Pavle Milutinović, Miloš Šabanović, Ivana Djukić.

INOSTRANI STUDENTI koji su bili na naučnoj razmeni pod direktnom supervizijom nekog od članova Laboratorije (prikazano sumarno):

Matthew Curran, Kanada; Valle Tania, Brazil; Rouf Sarhan, Egipat; Sofia Tessari, Francuska; Orita Mai, Japan; Gabriel Demchak, Kanada; Paolo Miccice, Italija; Carlo Chessari, Italija; Marie Bastrash, Kanada; Aksoy Yaner, Turska; Aida Martinez, Španija; Samuel Diaz, Španija; Cheima Doubi, Tunis; Petra Albuhosen, Liban; Lujza Strigacova, Slovenija; Bianca Ichim, Ruminija; Catalina Mijea, Rumunija; Antonio Pinazzi, Italija; Wang Han Yun, Tajvan; Xavier Sabate, Španija; Luis Gonzales, Meksiko; Irving Armando, Meksiko; Simone Marchini, Italija; Paolo Rodi, Italija

Rukovodilac laboratorije: Prof. dr Kristina Gopčević
Oblast rada:

• Ispitivanje markera oksidativnog stresa, markera oštećenja ćelijske membrane i matriksnih metaloproteinaza u odabranim patološkim stanjima
• Ispitivanje hemijskog sastava i farmakološkog dejstva prirodnih lekovitih sirovina biljnog porekla
• Karakterizacija proteoma toksina poskoka Vipera ammodytes ammodytes

Kontakt telefon: +381 11 3607 136
Kontakt el. adresa: kristina.gopcevic@med.bg.ac.rs
Adresa: Institut za hemiju u medicini Prof. dr Petar Matavulj, ul. Višegradska 26-2, 11129 Beograd, Srbija

Godina početka rada: 2000.

Istraživači:

• Prof. dr Kristina Gopčević
• Doc. dr Lidija Izrael Živković
• As. Ana Medić
• Dr Sandra Radenković
• Dr Branislav Rovčanin
• Dr Dušan Kekić
• Dr Tamara Filipović

Doktorandi:

• Dr Sandra Radenković, Medicinski fakultet (odbranila tezu 2013), Mentor
• Dr Branislav Rovčanin, Medicinski fakultet (odbranio tezu 2017), Komentor
• Dr Dušan Kekić, Medicinski fakultet (2018-), Komentor
• Dr Tamara Filipović, Medicinski fakultet (2018-), Komentor
• Mr Ksenija Stojanović Hemijski fakultet (odbranila tezu 2004), član komisije
• Mr Vesna Pavelkić, Fakultet za fizičku hemiju (odbranila tezu 2006), član komisije
• Mr Radivoje Anđelković, Fakultet veterinarske medicine (odbranila tezu 2007), član komisije
• Dr Danijela Ristić Medić, Medicinski fakultet (odbranila tezu 2010), član komisije
• Dr Katarina Mirjačić Martinović, Medicinski fakultet (odbranila tezu 2014), član komisije
• Dr Slavica Mutavdžin, Medicinski fakultet, (2017-) član komisije
• Dr Dušan Todorović, Medicinski fakulltet, (2019-) član komisije

Magistrandi:

• Svetlana Trajković, dipl. ing. hemije, Fakultet veterinarske medicine, (odbranila tezu 2004), član komisije)
• Nataša Kilibarda, fakultet veterinarske medicine (odbranila tezu 2006), član komisije

Specijalizanti:

• Saša Živković, dipl. vet., Fakultet veterinarske medicine, (odbranila tezu 2009), član komisije
• Dr Sandra Radenković, Medicinski fakultet (odbranila rad 2007)

Diplomci:

• Dušan Kekić, Medicinski fakultet, 2012, Mentor
• Dejan Perković, Medicinski fakultet, 2013, Mentor
• Nikola Pozojević, Medicinski fakultet, 2013, Mentor
• Uroš Popović, Medicinski fakultet, 2013, Mentor
• Slobodan Perić, Medicinski fakultet, 2015, Mentor
• Miloš Pešić, Medicinski fakultet, 2015, Mentor
• Milica Vučetić, Medicinski fakultet, 2015, Mentor
• Matija Đukić, Medicinski fakultet, 2015, Mentor
• Dunja Cimeša, Medicinski fakultet, 2017, Mentor
• Ivana Pavlović, Medicinski fakultet, 2017, Mentor
• Marija Šinik, Medicinski fakultet, 2018, Mentor
• Đorđe Antonić, Medicinski fakultet, 2014, (član komisije)
• Nataša Kovačević, Medicinski fakultet, 2017 (član komisije)
• Nikola Ignjatović, Medicinski fakultet, 2017 (član komisije)
• Jovana Polić, Medicinski fakultet, 2017, (član komisije)
• Nataša Doronjga, Medicinski fakultet, 2017, (član komisije)
• Slađana Živanović, Medicinski fakultet, 2017 (član komisije)
• Sloba Ristanović, Medicinski fakultet, 2018 (član komisije)

Studenti:

• Branislav Rovčanin, 2006
• Dušan Kekić, 2008
• Matija Đukić, 2013
• David Ivanović, 2013
• Jelena Mudrić, Farmaceutski fakultet, 2017
• Kristina Đorđević, Medicinski fakultet, 2017
• Marija Šinik, 2017
• Ana Ilić, Medicinski fakultet, 2018
• Lidija Isailović, Medicinski fakultet, 2018

Projekti:

• 2010-201 Osnovna istraživanja, oblast medicina. Molekulske, biohemijske i imunske analize u dijagnostici tumora. Broj 175056, rukovodilac prof. dr Vladimir Jurišić, Medicinski fakultet Univerziteta u Kragujevcu, istraživač
• 1986-1991. Osnovna istraživanja, oblast medicina. Medicinska istraživanja nervnog sistema, glavni rukovodilac makroprojekta: akademik prof. Dr Ljubisav Rakić. Medicinski fakultet Univerziteta u Beogradu. Podprojekat: Proučavanje dejstva zmijskog otrova na nervno mišićni sistem. Rikovodilac podprojekta prof. Dr Miodrag Cvetković, Medicinski fakultet Univerziteta u Beogradu,  istraživač
• 1990-1995. Osnovna istraživanja, oblast hemija. Ispitivanje markera balkanske endemske nefropatije. Rukovodilac projekta prof. dr Dušan Vučelić, Institut za opštu i fizičku hemiju, Beograd, istraživač
• 1995-2000. Osnovna istraživanja, oblast medicina. Nervna i humoralna regulacija kardiovaskularnog sistema u postnatalnom razvoju. Rukovodilac projekta prof. Dr Mirjana Pavlović, Medicinski fakultet Univerziteta u Beogradu, istraživač
• 2001-2004. Osnovna istraživanja, oblast hemija. Metabolička aktivnost nekih osobenih mikroorganizama kao izvora biološki aktivnih supstanci i transformacija prirodnih i sintetičkih supstrata. Rukovodilac projekta prof dr Miroslav Vrvić, Hemijski fakultet Univerziteta u Beogradu, istraživač
• 2001-2005. Primenjena istraživanja, oblast hemija. Primena metaboličke aktivnosti nekih osobenih mikroorganizama kao izvora biološki aktivnih supstanci i transformacija prirodnih i sintetičkih supstrata. Rukovodilac projekta prof dr Miroslav Vrvić, Hemijski fakultet Univerziteta u Beogradu, istraživač
• 2005-2008. Tehnološki razvoj, oblast veterina. Optimizacija procesa proizvodnje toplo dimljene pastrmke. Rukovodilac projekta prof. Dr Milan baltić, Fakultet veterinarske medicine, Univerziteta u Beogradu, istraživač
• 2010-2015. Osnovna istraživanja, oblast medicina. Laboratorijski markeri kao rani pokazatelji invazivnih mikoza. Rukovodilac projekta Prof. dr Valentina Arsić Arsenijević, Medicinski fakultet Univerziteta u Beogradu, istraživač

Međunarodni projekti:

• 2019-2023 COST Action CA 18216 Network for Research in Vascular Ageing (VascAgeNet)

Radovi:

• Gopčević K., Grujić S., Arsenijević J., Karadžić I., Izrael-Živković L., Maksimović Z. Phytochemical Properties of Satureja kitaibelii, Potential Natural Antioxidants: a New Insight. Plant Foods for Human Nutrition (2019) 74:179-184.  IF 2.598
• Branislav Rovcanin, Kristina Gopcevic, Dusan Kekic, Vladan Zivaljevic, Aleksandar Diklic, Svetislav Tatic, Milan Jovanovic, Bozidar Odalovic, Ivan Paunovic. Redox metabolism correlates with cellular turnover and clinical phenotype of papillary thyroid carcinoma and colloid goiter. Arch Med Sci DOI:https://doi.org/10.5114/aoms.2019.88347 IF 2.380
• Mutavdzin S, Gopcevic K, Stankovic S, Jakovljevic Uzelac J, Labudovic Borovic M, Djuric D. The Effects of Folic Acid Administration on Cardiac Oxidative Stress and Cardiovascular Biomarkers in Diabetic Rats. Oxid Med Cell Longev 2019 Jun 11; 1342549  IF 4.868
• Mutavdzin S, Gopcevic K, Stankovic S, Jakovljevic Uzelac J, Labudovic Borovic M, Djuric D. The effect of folic acid administration on cardiac tissue matrix metalloproteinase activity and hepatorenal biomarkers in diabetic rats. Can J Physiol Pharmacol. 2019 Sep ;97(9):893-901 IF 2.041
• Veskovic M, Mladenovic D, Milenkovic M, Tosic J, Borozan S, Gopcevic K, Labudovic-Borovic M, Dragutinovic V, Vucevic D, Jorgacevic B, Isakovic A, Trajkovic V, Radosavljevic T. Betaine modulates oxidative stress, inflammation, apoptosis, autophagy, and Akt/mTOR signaling in methionine-choline deficiency-induced fatty liver disease. Eur J Pharmacol. 2019 Apr 5;848:39-48. IF 3.170
• Izrael-Zivkovic Lidija T  Rikalovic Milena G  Gojgic-Cvijovic Gordana Dj  Kazazic Sasa  Vrvic Miroslav M  Brceski Ilija D  Beskoski Vladimir P  Loncarevic Branka D  Gopcevic Kristina R  Karadzic Ivanka M. Cadmium specific proteomic responses of a highly resistant Pseudomonas aeruginosa san ai. RSC Advances 2018; 8(19): 10549-10560. IF 3.049
• Gopcevic K., Rovcanin B., Kekic D., Krivokapic Z., Dragutinovic V. Matrix metalloproteinase-2 and -9, lactate and malate dehydrogenase and lipid peroxides in sera of patients with colorectal carcinoma.  Folia Biologica (Praha) (2017) 63, 190-196. IF 1.044
• Gopcevic K., Rovcanin B., Kekic D., Milasinovic D., Kocic G., Stojanović I. Gelatinases A and B and antioxidant enzymes activity in the early phase of the acute myocardial infarction. Folia Biologica (Praha), (2017) 63: 20-26. IF 1.044
• Izrael-Živković L, Živković Lj, Beškoski V, Gopčević K, Jokić B, Radosavljević B, Karadžić I. The Candida rugosa lipase adsorbed onto titania as nanobiocatalyst with improved thermostability and reuse potential in aqueous and organic media. Journal of Molecular catalysis B, Enzymatic. (2016) 133, S533–S542. IF 2.269
• Rovčanin B, Gopčević K, Kekić D, Živaljević V, Diklić A, Paunović I. Papillary Thyroid Carcinoma: A Malignant Tumor with Increased Antioxidant Defense Capacity. Tohoku Journal of Experimental Medicine (2016) 240, 101-111. IF 1.278
• Radenković S., Konjević G., Jurišić V., Karadžić K., Nikitović M., Gopčević K.R. Values of MMP-2 and MMP-9 in Tumor Tissue of Basal-Like Breast Cancer Patients. Cell Biochemistry and biophysics (2014) 68: 143-152. IF 1.680
• Radenković Sandra S,  Konjević Gordana M,  Isaković  Aleksandra J, Stevanović Predrag D, Gopčević Kristina R, Jurišić Vladimir. HER2-Positive Breast Cancer Patients: Correlation between Mammographic and Pathological Findings. Radiation Protection and Dosimetry (2014) 162 (1-2): 125-128. IF  0.913
• Radenković S., Milošević Z., Konjević G., Karadžić K., Rovčanin B., Buta M., Gopčević K., Jurišić V. Lactate dehydrogenase, Catalase, and Superoxide dismutase in Tumor Tissue of Breast Cancer Patients in Respect to Mammographic Findings. Cell Biochemistry and Biophysics (2013) 66(2): 287-295 IF 2.380
• Gopčević K.R., Rovčanin B.R., Tatić S.B., Krivokapić Z.V., Gajić M.M., Dragutinović V.V. Activity of Superoxide Dismutase, Catalase, Glutathione Peroxidase, and Glutathione Reductase in Different Stages of Colorectal Carcinoma. Digestive Diseases and Sciences (2013) 58 (9), 2646-2652 IF 2.550
• Rastegari A.A., Buzari B., Pavelkić V., Gopčević K., Petković M., Bordbar A.K. Thermal denaturation of pepsin at acidic media: Using DSC, MALDI-TOF MS and PAGE techniques. Thermochimica Acta (2013) 568, 165-170., IF 2.105
• Pavelkić V.M., Beljanski M.V., Babić M.M., Brdarić T.P., Gopčević K.R. Thermal Stability of Porcine Pepsin Influenced by Al(III) Ion: DSC Study. Russian Journal of Physical Chemistry A. (2011) 85 (13): 2245-2250. IF 0.459
• Kojić Z., Gopčević K., Marinković D., Tasić G. Effects of Captopril on Serum Lipid Levels and Cardiac Mitochondrial Oxygen Consumption in Experimentally-Induced Hypercholesterolemia in Rabbits. Physiological Research (2011) 60: (Suopl. 1) 177-184. IF 1.555
• Gopčević K., Rovčanin B., Kekić D., Radenković S. Matrix metalloproteinases and membrane damage markers in sera of patients with acute myocardial infarction. Molecular and Cellular Biochemistry (2011) 350: 163-168. IF 2.057
• Radenković S., Brajović M., Konjević G., Gopčević K. Gelatinases A and B in the serum of patients with various coronary artery disease stages. Vojnosanitetski pregled (2010), 67 (10): 825-830. IF 0.199Stanković S., Konjević G., Gopčević K., Jović V., Inić M., Jurišić V. Activity of MMP-2 and MMP-9 in sera of breast cancer patients. Pathology Research and Practice (2010), 206 (4): 241-247. IF 1.258
• Bosnić O.M., Gopčević K. R., Vrvić M. M., Karadžić I.M. Inhibition of trypsin by heparin and dalteparin, a low molecular weight heparin, Journal of th Serbian Chemical Society (2009) 74 (4): 379-388. IF 0.820
• Izrael-Živković L.T., Gojgić-Cvijović G.Đ., Gopčević K.R., Vrvić M.M., Karadžić I.M. Enzymatic characterization of 30 kDa lipase from Pseudomonas aeruginosa ATCC 27853. Journal of Basic Microbiology (2009) 49: 1-11. IF 1.319
• Pavelkić V.M., Gopčević K. R., Krstić D. Z., Ilić M. A. The influence of Al³⁺ ions on porcine pepsin activity in vitro. Journal of  Enzyme Inhibition and Medicinal Chemistry (2008) 23 (6): 1002-1010. IF 1.421
• Pavelkić V.M., Stanisavljev D.R., Gopčević K.R., Beljanski M.V. Influence of microwave irradiation on enzyme kinetics, Russian Journal of Physical Chemistry A. (2009) 83 (9): 1-5.
• Okon E.B., Hranisavljević J., Marjanović V., Gopčević K., Pavlović N., Mitić B., Strahinjić R., Vučelić D., Kaminski Ju. Diurnal fluctuations of Protein Contents and the pH Dependence of β2-Microglobulin Stability in Urine. Biology Bulletin (2008) 35 (1): 37-42. IF 0.082
• Gopčević K., Gojgić-Cvijović G., Pavlović M., Milićević Ž., Stevanović D. The membrane active antibiotics effects on rat heart myocardium. Acta Veterinaria (Beograd), (2006) 56 (2-3): 149-156. IF  0.143
• Gopčević K., Bosnić O., Karadžić I., Pavlović M., Petković D., Cvetković M., Macut Đ., Vučetić J. The effect of prostacyclin (PgI2) on trypsin and proteinase K acitvity. Jugoslovenska medicinska biohemija, (2000) 19: 395-399. IF 0.059
• Gopčević K., Pavlović M., Milićević Ž., Stanković S. Protective role of amphotericin B in cardiotoxic effects of Vipera ammodytes snake venom. Acta biologica iugoslavica– serija C: Physiologica et pharmacologica acta (2005) 41 (1): 29-36. IF 0.012
• Gopčević K., Karadžić I., Izrael L., Pavlović M., Vučetić J. Proteolytic profile of Vipera ammodytes snake venom, Acta Veterinaria (Beograd), (2000) 50 (5-6): 345-354. IF 0.106
• Petković D., Pavlović M., Jovanović T., Panić-Držajić V., Zdjelar K., Unković S., Matejević D., Aleksić N., Cvetković M. Neutralization of the activity of Vipera ammodytes ammodytes snake venom on myocardium of rats by antitoxinum viperinum: a histopathological study. Journal de Toxicologie Clinique et Experimentele (1991) 11 (6): 343-347. IF 0.030

Ostali radovi:

• Vučetić J., Zdjelar K., Ćirović M., Vrvić M.M., Radovanović I., Đukanović Z. Ćelijski proteini i dobijanje antibiotika fermentacijom pomoću Actinomyces sp. 468. Acta biologica iugoslavica serija B , Mikrobiologija (1987) 24 (1): 19-26.
• Vučetić J., Gojgić-Cvijović G., Radovanović E., Zdjelar K., Karadžić I. Taksonomska karakterizacija soja Actinomyces sp. 468. Acta biologica iugoslavica serija B, Mikrobiologija (1989) 26 (1): 53-61.
• Zdjelar K., Karadžić I., Gojgić-Cvijović G., Vučetić JBiochemical study of Streptomyces hygroscopicus (Actinomycessp. 468)- nucleic acids. Acta biologica iugoslavica serija B,, Mikrobiologija, . (1991) 28 (2): 105-112.
• Gopčević K., Gojgić-Cvijović G., Karadžić I., Radovanović E., Vučetić J. Biochemical and morphological changes in antibiotic –producing strain Streptomyces hygroscopicus during submerged fermentation. Acta biologica iugoslavica serija B, Mikrobiologija (1997) 34 (1): 11-21.
• Gopčević K., Karadžić I., Gojgić-Cvijović G., Pavlović M., Milićević Ž., Vučetić J., Nešić M. Streptomyces hygroscopicus fermentation products influence on rat heart contractions. Acta biologica iugoslavica serija B, Mikrobiologija 1999, 36 (1): 119-127
• Gojgić-Cvijović G., Karadžić I., Gopčević K., Borozan S. The effect of rifamycin and chloramphenicol on antibiotic and protease production by Streptomyces hygroscopicus.  Acta biologica iugoslavica serija B, (2006) 43 (1): 31-40.
• Vučetić J., Karadžić I., Zdjelar K. Lubenica –gigantski plod. Hrana i ishrana 1991, 32 (2): 105-9.
• Vučetić J., Gopčević K. Joni i zdravlje čoveka. Hemijski pregled (1997) 38 (1-2): 24-29.
• Gopčević K., Karadžić I. O zmijskim otrovima, Hemijski pregled (1999) 40 (5-6): 97-101
• Vučetić J., Gojgić-Cvijović G., Gopčević K., Izrael L. Jestive gljive (pečurke)-cenjen proizvod ishrane, Hemijski pregled (2000) 41 (2): 51-55.
• Macut Đ., Micić D., Kendereški A., Šumarac-Dumanović A., Zorić S., Cvijović G., Mijović Z.,Bjekić J., Goldner B., Gopčević K. Ultrazvučno praćenje indukcije ovulacije u bolesnica sa sindromom policističnih ovarijuma. Scripta Medica (2000) 31 (2): 63-70. M53
• Vučetić J., Gopčević K., Dragutinović V., Simonović M. Vitamin C-vitamin zdravlja. Hemijski pregled (2003) 44 (2): 32-38.
• Vučetić J., Gojgić-Cvijović G., Gopčević K., Nastasijević B. Krompir (Solanum tuberosum L.) Hrana i ishrana, (2004) 45 (1-2): 10-15.
• Kristina Gopčević. Metaloproteinaze ćelijskog matriksa – struktura i funkcija, Hemijski pregled (2010) 51 (5): 111-117.
• B. Rovcanin, D. Kekic, S. Radenkovic, K. Gopčević. Use of enzymatic parameters in diagnosing lobular and fibrilar breast carcinoma. Journal of Biomedical and Clinical research (2011) 4(1): 30-36.
• Pavlović M., Petković D., Cvetković M., Zdjelar K., Starčević V., Bosnić O. Study of the mechanism of prostacyclin (PgI2) action on myocardial contractility. Agents and Actions Supplements, (1992) 37,171-5. (in Prostaglandins in Cardiovascular system, Eds. H. F. Sinzinger and K. Schror, Birkhauser Verlag, Basel, Boston, Berlin 1992.), 5^th International Symposium on Prostaglandins in the Cardiovascular System, Vienna1991, September 22^nd to 26^th.
• Pavlović M., Macut Đ., Nešić M., Bojić M., Cvetković M., Petković M., Pavlović D., Zdjelar K. Influence of alpha-adrenoceptor blockade on the inotropic effect of prostacyclin (PgI₂) Bulletin of Macedonian Pharmaceutical Association (1995) 41, 1-2, 232-233.
• Pavlović M., Nešić M., Zdjelar K., Petković D., Đurić D., Macut Đ., Pavlović D., Cvetković M., Nešić-Dorevska A. The endocardial endothelium modulates the effects of ouabain on the isolated right ventricle of rat heart. Proceedings of the 9th International Conference on Mechanics in Medicine and Biology (Ljubljana, Slovenia), (1996) 532-534.
• Joksić G., Krstić D., Krinulović K., Gopčević K. Metal ion effects on ATPases activity isolated from human lymphocytes. Physical Chemistry Proceedings, Vol. I of the 6^th International Conference of Fundamental and Applied Aspects of Physical Chemistry, (2002) September 26-28, Belgrade, Yugoslavia, 335-337.
• Pavelkić V., Gopčević K., Krstić D., Ilić M. Temperature and Al³⁺ ions influence on electrophoretic mobility of porcine pepsin. Physical Chemistry. (2006) Proceedings, Vol. I of the 8^th International Conference of Fundamental and Applied Aspects of Physical Chemistry, Belgrade, Serbia, 374-376
• Pavelkić V. M., Stanisavljev D.R., Gopčević K.R., Beljanski M.V.) Effects of microwave treated substrate on pepsin reaction kinetics. Physical Chemistry Proceedings of the 9th International Conference on Fundamental and Applied Aspects of Physical Chemistry, Vol. II Belgrade, Serbia, (2008) September 24-26, C-11-P, 166-168.
• Pavelkić V., Gopčević K., Krstić D., Ilić M., Pavelkić M. Non-essential activation of pepsin by Al³⁺ “in vitro”. Physical Chemistry Proceedings of the 9th International Conference on Fundamental and Applied Aspects of Physical Chemistry, Vol. II Belgrade, Serbia, (2008) September 24-26, F-15-P, 394-396.
• Pavelkić V., Beljanski M., Antić K., Babić M., Brdarić T., Gopčević K. Determination of ligand binding constants from DSC data. Physical Chemistry Proceedings of the 10th International conference on Fundamental and Applied aspects of Physical Chemistry. Vol I, (2010) Belgrade Serbia, September 21-24, p 343-346.

Rukovodilac laboratorije: ???
Oblast rada: ???

Kontakt telefon: ???
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Godina početka rada: ???

Istraživači:

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Projekti:

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Radovi:

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LABORATORIJA ZA MASENU SPEKTROMETRIJU PROTEINA

Rukovodilac laboratorije: V. prof. dr Lidija Izrael-Živković, diplomirani biohemičar sa doktoratom (Hemijski fakultet, Univerzitet u Beogradu) u oblasti strukture i funkcije proteina mikrobiloškog porekla.

Oblast rada: Laboratorija za masenu spektrometriju proteina poseduje kompletnu infrastukturu za analizu proteoma u rasponu od jednostavnih identifikacija proteina do složene analize koja uključuje tehnike višestepene separacije za razdvajanje proteina i peptida i najsavremeniju masenospektrometrijsku analizu kuplovanu sa metodama bioinformatike. Moderna analitička platforma za istaživanje proteoma obuhvata pripremu proteinskog uzorka, njegovu enzimsku digestiju, separaciju peptida HPLC, njihovu analizu masenom spektrometrijom i identifikaciju proteina bioinformatičkim metodama. Laboratorija za masenu spektrometriju proteina poseduje svu potrebnu opremu za ovu vrstu istraživanje: maseni spektrometar Bruker Daltonics, Amazon Speed kuplovanim sa tečnim hromatografom viskoh performani i autosamplerom nano-Advance UHPLC, vakuum koncentratorom Eppendorf Speedvac, generatorom azota Peak Scientific, kao i svom potrebnom opremom za pripremu uzoraka metodama preparativne biohemije.

Uz visoke zahteve vezane za skupu opremu, osnivanje i rad u Laboratorija za masenu spektrometriju proteina počiva na ekspertizi istraživača. Potreba znanja, kao i protokoli za rad u ovoj laboratoriji, su preneti iz prestižnih američkih laboratorija (University of Washington, Department of Medicinal Chemistry; University of Florida, Department of Microbiology and Cell Science) u kojima je prof. Karadžić radila na razvoju najnovijih (wet i dry) analitičkih metoda u tehnologiji proteomiksa, baziranog na strukturnoj masenoj spektrometriji i bioinformatici, kao i na aplikaciji metoda funkcionalnog proteomiksa.

Laboratorija za masenu spektrometriju proteina čine obučeni istraživači sa značajnim iskustvom u analizi proteoma o čemu svedoče njihove publikacije.

Kontakt telefon: 3607135

Kontakt el. adresa: lidija.izrael-zivkovic@med.bg.ac.rs

Adresa: Višegradska 26, Beograd

Godina početka rada: 2015

Istraživači:

• Dr Lidija Izrael-Živković, v. profesor
• Dr Ivanka Karadžić, profesor
• Dr Ana Medić, asistent
• Master Saša Vatić, asistent

Projekti :

• Nacionalni

1. Projekat III 43004 „Simultana bioremedijacija i soilifikacija degradiranih prostora, za očuvanje prirodnih resursa biološki aktivnih supstanci i razvoj i proizvodnju biomaterijala i dijetetskih proizvoda“, Hemija, 2011-2018, MPNTR, rukovodilac Dr Vladimir Beškoski, vanredni profesor Hemijskog fakulteta u Beogradu.

• Međunarodni

1. „Sequencing the genome of a novel Pseudomonas aeruginosa NCAIM (P) B 001380 strain useful in environmental protection and cleaning of heavily polluted spots”, (2011-2014). Joint Project: The Regents of the University of California, US Department of Energy and Faculty of Medicine of the University of Belgrade. Contract DE-AC02-05CH11231. Professor Ivanka Karadžić, Principal Investigator, Serbia (Contract and Project available; Project results available at: https://img.jgi.doe.gov/cgi-bin/m/main.cgi?section=TaxonDetail&page=taxonDetail&taxon _oid=2563366717.
2. „Capacity Building for Analysis and Reduction Measures of Persistent Organic Pollutants in Serbia“ (HF-2014-01); (2014 – 2017), Funded by: Japan International Cooperation Agency (JICA), (Tokyo, Japan), Project Leader Professor Associate Vladimir Beškoski.

Izabrani radovi

1. Medić A, Stojanović K, Izrael- Živković L, Beškoski V, Lončarević B, Kazazić S, Karadžić I, A comprehensive study of conditions of the biodegradation of a plastic additive 2,6-di-tert-butylphenol and proteomic changes in the degrader Pseudomonas aeruginosa san ai, RSC Advances 9 (2019) 23696- 23710. doi: 10.1039/c9ra04298a
2. Izrael‑Živković L, Beškoski V, Rikalović M, Kazazić S, Shapiro N, Woyke T, Gojgić‑Cvijović G, Vrvić M, Maksimović N, Karadžić I, High‑quality draft genome sequence of Pseudomonas aeruginosa san ai, an environmental isolate resistant to heavy metals, Extremophiles, 23 (2019)399–405. doi: 10.1007/s00792-019-01092-w
3. Izrael Živković L. I., Rikalović M., Gojgić-Cvijović G., Kazazić S., Vrvić M., Lončarević B., Gopčević K., Karadžić I. M., Cadmium specific proteomic responses of a highly resistant Pseudomonas aeruginosa san ai, RSC Advances 8 (2018) 10549- 10560. doi: 10.1039/c8ra00371h
4. Karadzic I., Maupin-Furlow J., Humbard M., Prunetti L., Singh P., Goodlett D., Chemical cross-linking, mass spectrometry, and in silico modeling of proteasomal 20S core particles of the haloarchaeon Haloferax volcanii, Proteomics 12 (2012) 1806-1814. doi: 10.1002/pmic.201100260
5. Kirkland P.A., Gil M.A., Karadzic I., Maupin- Furlow J., Genetic and proteomic analyses of the proteasome-activating nucleotidase a mutant of the haloarchaeon Haloferax volcanii, Journal of Bacteriology 190 (2008) 195-203. doi: 10.1128/JB.01196-07
6. Karadzic I., Maupin-Furlow J., Improvement of two-dimensional gel electrophoresis proteom maps of the haloarhaeon Haloferax volcanii, Proteomics, 5 (2005) 354-359. doi: 10.1002/pmic.200400950
7. Maupin-Furlow J., Gil M. A., Karadzic I., Kirkland P., Reuter C., Proteasomes: perspectives from the archaea, review, Frontiers in Bioscience, 9 (2004) 1743-1758. doi: 10.2741/1363
8. Karadžić I.M., Rikalović M. G., Izrael-Živković L. T., Medić A. B., Extremophilic isolates of Pseudomonas aeruginosa as biomarkers of presence of heavy metals and organic pollution and their potential for application in contemporary ecotoxicology, In “Extreme environments, Unique ecosystems – amazing microbes”, (Editors Anita Pandey and Avinash Sharma), chapter 20, pp 343- 358, CRC Press, Taylor & Francis Group, LLC, 2021. doi: 10.1201/9780429343452

9. Maupin-Furlow J., Karadžić I., Goodlett D., Structural mass spectrometry of halophilic proteasomal nanomachines using chemical cross-linking, In „Recent Advances in Proteomics Research“, chapter 7, pp-175-20, Nova Science Pub. Inc., New York, 2013 (Ming D., M.D. Li, Editors). doi: 10.5772/59739

LABORATORIJA ZA PROTEINSKU BIOHEMIJU

Rukovodilac laboratorije: Prof. dr Ivanka Karadžić, diplomirani hemičar sa doktoratom (Hemijski fakultet, Univerzitet u Beogradu) i obavljenim postdoktorskim studijama u oblasti strukture i funkcije proteina različitog biološkog porekla (University of Washington, Department of Medicinal Chemistry; University of Florida, Department of Microbiology and Cell Science; Technology Research Institute of Osaka Prefecture, Department of Materials, Group of Enzyme Engineering).

Oblast rada: Laboratorija se bavi biohemijom proteina što obuhvata: preparativnu biohemiju proteina, metode karakterizacije proteina, enzimologiju, kao i najnovije metode analize proteoma. Pored toga u laboratoriji se rade i sekundarni metaboliti kao deo hemije prirodnih proizvoda, u relaciji sa moduliranjem aktivnosti proteina. U laboratoriji se uspešno koriste analitičke metode najanovije generacije bazirane na strukturnoj masenoj spektrometriji i bioinformatici kao i metode funkcionalnog komparativnog proteomiksa u analizi proteinskog odgovora mikroorganizama na izlaganje toksičnim supstancama kao što su teški metali i organski zagađivači.

Ekotoksikoproteomiks zasnovan na metodama klasične biohemije proteina ali i multi- omiks analitičkim pristupima (posebno proteomiks i metabolomiks), kao i ispitivanje uticaja nanomaterijala na proteom i upotreba biokompatibilnih nanomaterijala u postupcima imobilizacije enzima su, od nedavno, glavne oblasti istraživanja u laboratoriji.

Metodologija istraživanja: Izolovanje i prečišćavanje proteina se izvodi sledećim metodama: precipitacija, jonoizmenjivačka i hidrofobna hromatografija, gel filtracija.

Karakterizacija proteina obuhvata klasične metode SDS PAGE i gel filtracije, kao i nove metode masene spektrometrije za određivanje molekulske mase i bioinformatike.

Funkcija proteina se ispituje enzimološkim analizama: merenje aktivnosti enzima; određivanje optimalne pH i temperature, pH i temperaturne stabilnosti; kinetika enzima: mono i više supstratnih reakcija; modulacija aktivnosti enzima autogenim i neautogenim inhibitorima; mehanizam višesupstratne kinetike korišćenjem studije inhibicije proizvodom i softverskih paketa.

U laboratoriji se uspešno rade i medtode imobilizacija enzima na različitim materijalima, a od nedavno na nanomaterijalima koji su biokompatibilni.

U okviru hemije prirodnih proizvoda u laboratoriji se rade izolovanje i prečišćavanje različitih mikrobnih metabolita, posebno antibiotika i inhibitora enzima; aktivni principi iz biljaka i njihova karaketizacija na osnovu spektralnih podataka (UV, IR, NMR).

Kontakt telefon: 3607067

Kontakt el. adresa: ivanka.karadzic@med.bg.ac.rs

Adresa: Višegradska 26, Beograd

Godina početka rada: 1995

Istraživači:

• Dr Ivanka Karadžić, profesor
• Dr Lidija Izrael-Živković, v. profesor
• Dr Ana Medić, asistent
• Master Saša Vatić, asistent

Projekti:

• Nacionalni

1. Projekat III 43004: „Simultana bioremedijacija i soilifikacija degradiranih prostora, za očuvanje prirodnih resursa biološki aktivnih supstanci i razvoj i proizvodnju biomaterijala i dijetetskih proizvoda“, Hemija, 2011-2018, MPNTR, rukovodilac Dr Vladimir Beškoski, vanredni profesor Hemijskog fakulteta u Beogradu
2. Projekat 142018b: ,,Biomasa i metabolizam nekih mikroorganizama kao široko upotrebljivih proizvoda i biohemijskih reakcija“. 2006-2010. Rukovodilac projekta prof. dr Miroslav M. Vrvić.
3. Projekat 1740: ,,Metabolička aktivnost nekih osobenih mikroorganizama kao izvor biološki aktivnih supstanci i transformacija prirodnih i sintetičkih supstrata“. 2000-2005. Rukovodilac projekta prof. dr Miroslav M. Vrvić.
4. Projekat 0295B: ,,Primena metaboličke aktivnosti nekih osobenih mikroorganizama kao izvor biološki aktivnih supstanci i transformacija prirodnih i sintetičkih supstrata“ . 2002-2004. Rukovodilac projekta prof. dr Miroslav M. Vrvić.
5. „Proučavanje biosinteze i degradacije kod specifičnih fiziološko-biohemijskih grupa mikroorganizama i njihova primena“. 1996-2000. Rukovodilac prof. dr Miroslav M. Vrvić.
6. „Normalni i izmenjeni metabolički putevi fiziološko-biohemijski specifičnih mikroorganizama, viših biljaka i čoveka“. 1991-1995. Rukovodilac prof. dr Jovan Vučetić.
7. „Biohemija prirodnih molekula: struktura, aktivnost i biosinteza“. 1986-1990. Rukovodilac prof. dr Jovan Vučetić.

• Međunarodni

1. „Sequencing the genome of a novel Pseudomonas aeruginosa NCAIM (P) B 001380 strain useful in environmental protection and cleaning of heavily polluted spots”, (2011-2014). Joint Project: The Regents of the University of California, US Department of Energy and Faculty of Medicine of the University of Belgrade. Contract DE-AC02-05CH11231. Professor Ivanka Karadžić, Principal Investigator, Serbia (Contract and Project available; Project results available at: https://img.jgi.doe.gov/cgi-bin/m/main.cgi?section=TaxonDetail&page=taxonDetail&taxon _oid=2563366717,
2. “Capacity Building for Analysis and Reduction Measures of Persistent Organic Pollutants in Serbia” (HF-2014-01); (2014 – 2017), Funded by: Japan International Cooperation Agency (JICA), (Tokyo, Japan), Project Leader Professor Associate Vladimir Beškoski.
3. „Strengthening the capacity for bilateral cooperation between IChTM (Institute of Chemistry, Technology and Metallurgy, Belgrade, Serbia) and HPIES (Hyogo Prefectural Institute of Environmental Sciences, Kobe, Japan) in order to produce joint research about presence and behavior of Persistent Organic Pollutants (POPs) in river sediments of Serbia“, 2012, Funded by: Japan International Cooperation Agency –JICA, Project Leader Professor Associate Vladimir Beškoski.

Izabrani radovi (od 2010)

1. Medić A., Lješević M., Inui H., Beškoski V., Kojić I., Stojanović K., Karadžić I. Efficient biodegradation of petroleum n-alkanes and polycyclic aromatic hydrocarbons by polyextremophilic Pseudomonas aeruginosa san ai with multidegradative capacity. RSC Advances 10 (2020) 14060-14070. doi: 10.1039/c9ra10371f
2. Medić A., Stojanović K., Izrael- Zivković L., Beškoski V., Lončarević B., Kazazić S., Karadžić I., A comprehensive study of conditions of the biodegradation of a plastic additive 2,6-di-tert-butylphenol and proteomic changes in the degrader Pseudomonas aeruginosa san ai, RSC Advances 9 (2019) 23696- 23710. doi: 10.1039/c9ra04298a
3. Izrael‑Živković L., Beškoski V., Rikalović M., Kazazić S., Shapiro N., Woyke T., Gojgić‑Cvijović G., Vrvić M., Maksimović N., Karadžić I., High‑quality draft genome sequence of Pseudomonas aeruginosa san ai, an environmental isolate resistant to heavy metals, Extremophiles, 23 (2019)399–405. doi: 10.1007/s00792-019-01092-w
4. Gopčević K., Grujić S., Arsenijević J., Karadžić I., Izrael-Živković L., Maksimović Z., Phytochemical Properties of Satureja kitaibelii, Potential Natural antioxidants: a New Insight, Plant Foods for Human Nutrition 74 (2019)179–184. doi: 10.1007/s11130-019-0716-3
5. Izrael Živković L.I., Rikalović M., Gojgić-Cvijović G., Kazazić S., Vrvić M., Lončarević B., Gopčević K., Karadžić I. M., Cadmium specific proteomic responses of a highly resistant Pseudomonas aeruginosa san ai, RSC Advances 8 (2018) 10549-10560. doi: 10.1039/c8ra00371h
6. Izrael Živković L.I., Živković Lj.S., Beškoski V., Gopčević K., Jokić B.M., Radosvaljević D., Karadžić I.M., The Candida rugosa lipase adsorbed onto titania as nano biocatalyst with improved thermostability and reuse potential in aqueous and organic media, Journal of Molecular Catalysis B: Enzymatic 133 (2016) S533–S542. doi: 10.1016/j.molcatb.2017.06.001
7. Izrael Živković L.I., Živković Lj.S., Jokić B.M., Savić A.B., Karadžić I.M., Adsorption of Candida rugosa lipase onto alumina: effect of surface charge, Journal of the Serbian Chemical Society 80 (2015). doi: 10.2298/JSC1500222035I
8. Grbavčić S., Bezbradica D., Karadzic I., Knežević-Jugović Z., Development of an environmentally acceptable detergent formulation for fatty soils based on the lipase from the indigenous extremophile Pseudomonas aeruginosa strain, Journal of Surfactants and Detergents 18 (2015) 383-395. doi:10.1007/s11743-015-1674-x
9. Izrael-Živković L., Živković, Lj., Karadžić I., Immobilisation of Candida rugosa lipase by adsorption onto biosafe meso/macroporous silica and zirconia, Biochemical Engineering Journal, 93 (2015) 73–83. doi: 10.1016/j.bej.2014.09.012
10. Bihelovic F., Karadzic I., Matovic R., Saicic R., Total synthesis and biological evaluation of (-)-atrop-abyssomicin, Organic & Biomolecular Chemistry 11 (2013) 5385–5548. doi: 10.1039/C3OB40692J
11. Rikalovic M., Abdel-Mawgoud A.M., Déziel E., Gojgic-Cvijovic G., Zorica Z., Vrvic M., Karadzic I., Comparative analysis of rhamnolipids from novel environmental isolates of Pseudomonas aeruginosa, Journal of Surfactants and Detergents 16 (2013) 673-682. doi: 10.2298/JSC110211156R
12. Karadzic I., Maupin-Furlow J., Humbard M., Prunetti L., Singh P., Goodlett D., Chemical cross-linking, mass spectrometry, and in silico modeling of proteasomal 20S core particles of the haloarchaeon Haloferax volcanii, Proteomics 12 (2012) 1806-1814. doi: 10.1002/pmic.201100260
13. Grbavčić S., Bezbradica D., Izrael- Živković L., Avramović N., Milosavić N., Karadzic I., Knežević-Jugović Z., Production of lipase and protease from an indigenous Pseudomonas aeruginosa strain and their evaluation as detergent additives: Compatibility study with detergent ingredients and washing performance, Bioresource Technology 102 (2011) 11226-11233. doi: 10.1016/j.biortech.2011.09.076
14. Izrael-Zivkovic L., Gojgic-Cvijovic G., Karadzic I., Isolation and partial characterization of protease from Pseudomonas aeruginosa ATCC 27853, Journal of the Serbian Chemical Society 75 (2010) 1041-1062. doi: 10.2298/JSC1001250881

LABORATORIJA ZA ENZIMOLOGIJU I in vitro TOKSIKOLOGIJU

Rukovodilac laboratorije:  Prof. dr Danijela Krstić,

Institut za hemiju u medicini, Medicinski fakultet Univerziteta u Beogradu

Oblasti rada:

1) Ispitivanja modulacije aktivnosti „target“ enzima (ATPaze, holinesteraze,..) i biomarkera toksičnosti  (parametara oksidativnog stresa  i markera oštećenja ćelijske membrane)  u prisustvu:

1. a) toksičnih (organskih i neorganskih) supstanci: organofosfatnih pesticida i njihovih degradacionih proizvoda, jona teških metala itd.

b) novosintetisanih jedinjenja koja pokazuju potencijalnu primenu u terapiji nekih neuroloških bolesti, tumora i dijabetesa (nanoklasteri na bazi prelaznih metala, specifični inhibitori natrijumove pumpe,..), korišćenjem različitih eksperimentalnih (in vitro i in vivo) model sistema.

2) Ispitivanja odnosa između hemijske strukture i biološke aktivnosti/toksičnosti ispitivanih jedinjenja

Kontakt telefon: +381 3607 133
Kontakt el. adresa:  danijela.krstic@med.bg.ac.rs
Adresa: Institut za hemiju u medicini, Medicinski fakultet Univerziteta u Beogradu, Višegradska 26

Godina početka rada: 2001. god.

Istraživači:

• Pored nastavnika i saradnika Instituta za hemiju u medicini, u rad laboratorije uključena je dr Mirjana Čolović, Viši naučni saradnik, Laboratorija za fizičku hemiju, Institut za nuklearne nauke „Vinča“ Univerziteta u Beogradu.

Projekti: domaći, finansirani od strane Ministarstva nauke Republike Srbije:

• od 2002. do 2005. godine: „Fizičko-hemijska ispitivanja mehanizma reakcija biološki aktivnih organskih jedinjenja“(br.1991) – saradnik
• od 2006. do 2010. godine: „Istraživanje mehanizama interakcija biološki aktivnih jedinjenja sa biomolekulima“ (br. 142051) – saradnik
• od 2011. „Istraživanja interakcija enzima sa toksičnim i farmakološki aktivnim molekulima“  (br. 172023) -podrukovodilac

Projekti: međunarodni

• „Experimental and theoretical studies of some polyoxovanadates interaction with Na⁺/K⁺-ATPase and Ca²⁺-ATPase”, (br. 69-00-4/2012-09/04), u okviru bilateralne saradnje između Srbije i Francuske, 2011-2012. Rukovodioci (sa srpske strane): dr Danijela Krstić, (sa francuske strane): Prof. Anne Spasojević-de Biré.

Finansiranje: Centre national de la recherche scientifique i Ministarstvo prosvete, nauke i tehnološkog razvoja Republike Srbije

• „Polyoxopalladates: ATPases inhibition studies and toxicity evaluation”, (br. 451-03-01038/2015-09/16), u okviru bilateralne saradnje između Srbije i Nemačke, 2016-2017. Rukovodioci (sa srpske strane): dr Danijela Krstić, (sa nemačke strane): Prof. Ulrich Kortz.

Finansiranje: Deutscher Akademischer Austauschdienst–DAAD i Ministarstvo prosvete, nauke i tehnološkog razvoja Republike Srbije.

• „Polyoxometalates as potential anticancer and anti-Alzheimer drugs: modulation of Na⁺,K⁺ -ATPase and acetylcholinesterase activity”, (br. 451-03-01039/2015-09/18), u okviru bilateralne saradnje između Srbije i Austrije, 2016-2017. Rukovodioci (sa srpske strane):dr Mirjana Čolović, (sa austrijske strane): Prof. Annette Rompel

Finansiranje: Austrian agency for international mobility and cooperation in education, science and research i Ministarstvo prosvete, nauke i tehnološkog razvoja Republike Srbije.

• „Inhibitori acetilholinesteraze kao potencijalni terapeutici za Alchajmerovu bolest: prooksidativna i citogenotoksična svojstva (SafeAChE)“,  (br. 337-00-205/2019-09/19), u okviru bilateralne saradnje između Srbije i Hrvatske, 2019-2021. Rukovodioci (sa srpske strane):dr Mirjana Čolović, (sa hrvatske strane): dr Goran Gajski

Finansiranje: Ministarstvo prosvete, nauke i tehnološkog razvoja Republike Srbije i Ministarstvo znanosti i obrazovanja Republike Hrvatske.

• „In vitro and in vivo evaluation of novel polyoxometalate based contrast agents for micro computed tomography (POMCACT)”, u okviru Programa saradnje srpske nauke sa dijasporom, 2020-202 Rukovodilac (PI): Prof. dr Danijela Krstić, Project partner: Prof. dr Tatjana Parac-Vogt, KU Leven, Belgija.

Finansiranje: Fond za nauku Republike Srbije.

• „Polyoxovanadates as promising anticancer drug candidates: modulation of Na⁺,K⁺-ATPase and ecto-nucleoside triphosphate diphosphohydrolases (E-NTPDases) activity (POVaCan)” (br. 451-02-818/2021-09/01, u okviru bilateralne saradnje između Srbije i Kine, 2021-2023. Rukovodioci (sa srpske strane):dr Mirjana Čolović, (sa kineske strane): Prof. Yongge Wei

Finansiranje: Ministarstvo prosvete, nauke i tehnološkog razvoja Republike Srbije i         Ministarstvo za nauku i tehnologiju Narodne Republike Kine.

Izabrani radovi:

Radovi u međunarodnim časopisima izuzetne vrednosti (M21a):

[1] Lefranc F, Mijatović T, Kondo Y, Sauvage S, Roland I, Krstić D, Vasić V, Gailly P, Kondo S, Blanco G, Kiss R.  Targeting the a1 subunit of the sodium pump to combat glioblastoma cells, Neurosurgery, (2008), 62(1), 211-222. https://doi.org/10.1227/01.NEU.0000311080.43024.0E

[2] Dinčić M, Krstić D*, Čolović M, Nešović-Ostojić J, Kovačević S, de Luka S, Djordjević D, Ćirković S, Brkić P, Todorović J. Modulation of rat synaptosomal ATPases and acetylcholinesterase activities induced by chronic exposure to the static magnetic field. International Journal of Radiation Biology, (2018), 94 (11), 1062-1071. https://doi.org/10.1080/09553002.2018.1518611

[3] Yang P, Ma T, Lang Z, Misirlic-Dencic S, Isakovic A, Benyei A,  Čolović M, Markovic I, Krstić D, Poblet J, Lin Z, Kortz U. Tetravalent Metal Ion Guests in Polyoxopalladate Chemistry: Synthesis and Anticancer Activity of [MO₈Pd₁₂(PO₄)₈]¹²⁻ (M = SnIV, PbIV). Inorganic Chemistry, (2019), 58 (17), 11294-11299. https://doi.org/10.1021/acs.inorgchem.9b01129

 

 

Radovi u vrhunskim časopisima međunarodnog značaja (M21):

[1] Vasić V, Momić T, Petković M, Krstić D. Na⁺/K⁺-ATPase as the Target Enzyme for Organic and Inorganic Compounds, Sensors (2008), 8(12), 8321-8360. https://doi.org/10.3390/s8128321

[2] Čolović M, Krstić D, Petrović S, Leskovac A, Joksić G, Savić J, Franko M, Trebše P, Vasić V, Toxic effects of diazinon and its photodegradation products, Toxicology Letters, (2010), 193(1), 9-18. https://doi.org/10.1016/j.toxlet.2009.11.022

[3] Čolović M, Krstić D, Ušćumlić S, Vasić V. Single and simultaneous exposure of acetylcholinesterase to diazinon, chlorpyrifos and their photodegradation products, Pesticide Biochemistry and Physiology, (2011), 100(1), 16-22. https://doi.org/10.1016/j.pestbp.2011.01.010

[4] Petrović V, Čolović M, Krstić D, Vujačić A, Petrović S, Joksić G, Bugarčić Ž, Vasić V. In vitro effects of some gold complexes on Na⁺/K⁺ ATPase activity and cell proliferation. Journal of Inorganic Biochemistry, (2013), 124, 35–41. https://doi.org/10.1016/j.jinorgbio.2013.03.013

[5] Hrnčić D, Rašić-Marković A, Leković J,  Krstić D,  Čolović M, Macut Dj,  Šušić V,  Djurić D,  Stanojlović O. Exercise Decreases Susceptibility to Homocysteine Seizures: the Role of Oxidative Stress. International  Journal of Sports Medicine, (2014), 35 (7), 544-550. DOI: 10.1055/s-0033-1357162 https://eref.thieme.de/FFWPR

[6] Čolović M, Vasić,  Avramović  N,  Gajić M,  Djurić D,  Krstić D.* In vitro evaluation of neurotoxicity potential and oxidative stress responses of diazinon and its degradation products in rat brain synaptosomes, Toxicology Letters, (2015), 233 (1), 29-37. https://doi.org/10.1016/j.toxlet.2015.01.003

[7] Krstić D,*  Tomić  N, Radosavljević B, Avramović N,  Dragutinović V, Radojević Škodrić  S,  Čolović M. Biochemical Markers of Renal Function. Current Medicinal Chemistry (2016), 23(19), 2018-2040. https://doi.org/10.2174/0929867323666160115130241

[8] Xu X, Bošnjaković-Pavlović N, Čolović M, Krstić D*, Vasić V, Gillet JM, Wu P, Wei Y, Spasojević-de Biré A. A combined crystallographic analysis and ab initio calculations to interpret the reactivity of functionalized hexavanadates and their inhibitor potency toward Na⁺/K⁺-ATPase. Journal of Inorganic Biochemistry (2016), 161, 27–36. https://doi.org/10.1016/j.jinorgbio.2016.04.029

[9]  Čolović M, Medić B, Ćetković M, Kravić Stevović T, Stojanović M, Ayass W, Mougharbel A, Radenković M, Prostran M, Kortz U, Krstić D.* Toxicity evaluation of two polyoxotungstates with anti-acetylcholinesterase activity. Toxicology and Applied Pharmacology, (2017), 333, 68-75. https://doi.org/10.1016/j.taap.2017.08.010

[10] Čolović M, Vasić V, Djurić D, Krstić D.* Sulphur-containing amino acids: protective role against free radicals and heavy metals. Current Medicinal Chemistry, (2018), 25(3), 324-335.  https://doi.org/10.2174/0929867324666170609075434

[11] Bošnjaković-Pavlović N, Xu X, Krstić D, Gillet JM, Wei Y, Wu P,  Čolović M, Spasojevic-de Bire A. Experimental and theoretical insights of functionalized hexavanadates on Na⁺/K⁺-ATPase activity; molecular interaction field, ab initio calculations and in vitro assays.  Journal of Inorganic Biochemistry, (2019), 198, Article number 110720 https://doi.org/10.1016/j.jinorgbio.2019.110720

[12]  Čakar U, Čolović M, Milenković D, Medić B, Krstić D*, Petrović A, Ðordević B. Protective Effects of Fruit Wines against Hydrogen Peroxide—Induced Oxidative Stress in Rat Synaptosomes. Agronomy 2021, 11, 1414. https://www.mdpi.com/2073-4395/11/7/1414

[13]  Isakovic AM, Čolović MB, Ma T, Ma X, Jeremic M, Gerić M, Gajski G, Misirlic-Dencic S, Kortz U, Krstić D*. Selected polyoxopalladates as promising and selective antitumor drug candidates. Journal of biological inorganic chemistry 2021, 26(8):957-971. doi: 10.1007/s00775-021-01905-4. Epub 2021 Sep 21. PMID: 34549367. https://link.springer.com/article/10.1007/s00775-021-01905-4

Radovi u istaknutim časopisima međunarodnog značaja (M22):

[1] Krstić D, Krinulović K, Spasojević-Tišma V, Joksić G, Momić T, Vasić V. Effects of digoxin and gitoxin on the enzymatic activity and kinetic parameters of Na⁺/K⁺-ATPase, Journal of Enzyme Inhibition and Medicinal Chemistry, (2004), 19 (5), 409 – 415. https://doi.org/10.1080/14756360410001722065

[2] Krstić D, Krinulović K, Vasić V. Inhibition of Na⁺/ K⁺-ATPase and Mg²⁺-ATPase by metal ions and prevention and recovery of inhibited activities by chelators, Journal of Enzyme Inhibition and Medicinal Chemistry, (2005), 20 (5), 469 – 476. https://doi.org/10.1080/14756360500213280

[3] Krstić D, Tomić N, Krinulović K, Vasić V. The influence of potassium ion (K⁺) on digoxin-induced inhibition of porcine cerebral cortex Na⁺/K⁺-ATPase, Journal of Enzyme Inhibition and Medicinal Chemistry, (2006), 21 (4), 471-475.   https://doi.org/10.1080/14756360600642230

[4]  Čolović M, Bajuk-Bogdanović D, Avramović N, Holclajtner-Antunović I, Bošnjaković-Pavlović N, Vasić V, Krstić D*. Inhibition of rat synaptic membrane Na⁺/K⁺-ATPase and ecto-nucleoside triphosphate diphosphohydrolases by 12-tungstosilicic and 12-tungstophosphoric acid, Bioorganic and Medicinal Chemistry (2011), 19(23), 7063–7069. https://doi.org/10.1016/j.bmc.2011.10.008

[5] Čolović M, Krstić D*, Lazarević-Pašti T, Bondžić A, Vasić V. Acetylcholinesterase Inhibitors: Pharmacology and Toxicology. Current Neuropharmacology, 2013, 11(3), 315-335. https://dx.doi.org/10.2174%2F1570159X11311030006

[6] Dinčić M, Čolović M, Sarić Matutinović M, Ćetković M, Kravić Stevović T, Mougharbel A, Todorović J, Ignjatović S, Radosavljević B, Milisavljević M, Kortz U, Krstić D*. In vivo toxicity evaluation of two polyoxotungstates with potential antidiabetic activity using Wistar rats as a model system. RSC Advances, (2020), 10, 2846 – 2855. https://doi.org/10.1039/C9RA09790B

[7] Van Gool A, Corrales F, Čolović M, Krstić D, .. Luider T, Wittfooth S, Sammar M. Analytical techniques for multiplex analysis of protein biomarkers. Expert Review of Proteomics, (2020), 17(4), 257-273. https://www.tandfonline.com/doi/full/10.1080/14789450.2020.1763174

 

Radovi u časopisima međunarodnog značaja (M23):

[1] Krstić D,* Čolović M, Krinulović K, Djurić D, Vasić V. Inhibition of AChE by single and simultaneous exposure to malathion and its degradation products, General Physiology and Biophysics, (2007), 26, 247-253. https://pubmed.ncbi.nlm.nih.gov/18281741/

[2] Krstić D, Čolović M, Bavcon Kralj M, Trebše P, Krinulović K, Vasić V. The influence of malathion and its decomposition products on free and immobilized acetylcholinesterase, Russian Journal of Physical Chemistry, (2008), 82 (4), 663-668.   https://doi.org/10.1134/S0036024408040274

[3] Krstić D, Čolović M, Bavcon Kralj M, Franko M, Krinulović K, Trebše P, Vasić V. Inhibition of AChE by malathion and some structurally similar compounds, Journal of Enzyme Inhibition and Medicinal Chemistry, (2008), 23(4), 562-573.  https://doi.org/10.1080/14756360701632031

[4] Krstić D*, Čolović M, Bošnjaković-Pavlović N, Spasojević-de Bire A, Vasić V. Influence of Decavanadate on Rat Synaptic Plasma Membrane ATPases Activity, General Physiology and Biophysics, (2009), 28, 302-308. https://www.sav.sk/index.php?lang=en&doc=journal-list&part=article_response_page&journal_article_no=8974

Laboratorija za infodemiologiju i upravljanje infodemijom

Rukovodilac laboratorije: Asist. dr sc. med. Stefan Mandić-Rajčević, viši naučni saradnik
Oblast rada: infodemiologija, zdravstvena pismenost, digitalna pismenost, bihejvioralni uvidi za zdravlje, komunikacija rizika, vanredne situacije

Kontakt telefon: +381 11 2685451
Kontakt el. adresa: stefan.mandic-rajcevic@med.bg.ac.rs
Adresa: Dr Subotića Starijeg 15, 11000 Beograd

Godina početka rada: 2022

Istraživači:

• Prof. dr Aleksandra Jović-Vraneš
• Asist. dr Aleksandar Stevanović
• Doc. dr Jovana Todorović
• Doc. dr Smiljana Cvjetković
• Doc. dr Vida Stojković
• Dr Nikola Ilić

Studenti:

• Maša Petrović
• Lazar Petrović
• Miloš Jovanović
• Ognjen Krčmar

Projekti:

• 2022/2023, “Implementation of Infodemic Management activities in Serbia relevant to COVID-19 vaccination roll-out” (World Health Organization)

Odabrani radovi:

• Wilhelm, E., Ballalai, I., Belanger, M.E., Benjamin, P., Bertrand-Ferrandis, C., Bezbaruah, S., Briand, S., Brooks, I., Bruns, R., Bucci, L.M., Calleja, N.,… Mandić-Rajčević, S.,… Stevanović, A.,… and Purnat T. 2023. Measuring the Burden of Infodemics: Summary of the Methods and Results of the Fifth WHO Infodemic Management Conference. JMIR Infodemiology, 3(1), p.e44207. https://doi.org/10.2196/44207

• Cvjetkovic, Smiljana, Vida Jeremic Stojkovic, Stefan Mandic-Rajcevic, Sanja Matovic-Miljanovic, Janko Jankovic, Aleksandra Jovic Vranes, Aleksandar Stevanovic, and Zeljka Stamenkovic. 2022. „Societal Trust Related to COVID-19 Vaccination: Evidence from Western Balkans“ Sustainability 14, no. 20: 13547. https://doi.org/10.3390/su142013547
• Prijić A, Gazibara T, Prijić S, Mandić-Rajčević S, Maksimović N. Factors Associated with the Antibiotic Treatment of Children Hospitalized for COVID-19 during the Lockdown in Serbia. Int J Environ Res Public Health. 2022 Nov 24;19(23):15590. doi: 10.3390/ijerph192315590. PMID: 36497665; PMCID: PMC9737727.
• Vuković A, Mandić-Rajčević S, Sava-Rosianu R, D Betancourt M, Xhajanka E, Hysenaj N, Bajric E, Zukanović A, Philippides V, Zosimas M, Nikolaos M, Vlahović Z, Denkovski M, Peric T, Markovic D, Campus G. Pediatric Dentists’ Service Provisions in South-East Europe during the First Wave of COVID-19 Epidemic: Lessons Learned about Preventive Measures and Personal Protective Equipment Use. Int J Environ Res Public Health. 2021 Nov 10;18(22):11795. doi: 10.3390/ijerph182211795. PMID: 34831551; PMCID: PMC8622949.
• Terzic-Supic Z, Todorovic J, Bajcetic M, Jankovic J, Santric-Milicevic M, Stamenkovic Z, Djikanovic B, Mandic-Rajcevic S, Piperac P, Jovic-Vranes A, Matejic B. Knowledge, attitudes and practices and fear of COVID-19 among medical students in Serbia. J Infect Dev Ctries. 2021 Jun 30;15(6):773-779. doi: 10.3855/jidc.14298. PMID: 34242185.
• Dinić M, Šantrić Milićević M, Mandić‐Rajčević S, Tripković K. Health workforce management in the context of the COVID‐19 pandemic: A survey of physicians in Serbia. The international Journal of Health planning and Management. 2021 May;36(S1):92-111.
• Mandić-Rajčević S, Masci F, Crespi E, Franchetti S, Longo A, Bollina I, Velocci S, Amorosi A, Baldelli R, Boselli L, Negroni L. Source and symptoms of COVID-19 among hospital workers in Milan. Occupational Medicine. 2020 Dec;70(9):672-9.
• Crespi E, Velocci S, Masci F, Mandić-Rajčević S, Bollina I, Franchetti S, Longo A, Colosio C. Developing approaches to control SARS-CoV-2 in a public hospital. Occupational Medicine. 2020 Jul 17;70(5):311-.
• Lapčević Z, Mandić-Rajčević S, Lepić M, Jovanović M. Evaluating a primary healthcare centre’s preparedness for disasters using the hospital safety index: lessons learned from the 2014 floods in Obrenovac, Serbia. International journal of disaster risk reduction. 2019 Mar 1;34:436-42.

Učešće na konferencijama:

• S Mandić-Rajčević, J Janković, S Cvjetković, V Jeremić-Stojković, S Matović-Miljanović, A Stevanović, M Gross. Gender differences in COVID-19 vaccine hesitancy in Western Balkans. 17th World Congress on Public Health, May 2-6 2023. Rome, Italy.
• S Cvjetkovic, V Jeremic Stojkovic, J Jankovic, S Mandic-Rajcevic, Do religious people in Western Balkans have faith in COVID-19 vaccines?, European Journal of Public Health, Volume 32, Issue Supplement_3, October 2022, ckac131.359, https://doi.org/10.1093/eurpub/ckac131.359
• Cvjetkovic S, Jeremic-Stojkovic V, Mandic-Rajcevic S, Jankovic J. Does it matter who addresses whom in vaccination promotion campaign?. European Journal of Public Health. 2022 Oct;32(Supplement_3):ckac129-737.
• Matovic-Miljanovic S, Cvjetkovic S, Jeremic-Stojkovic V, Mandic-Rajcevic S, Bjegovic-Mikanovic V, Gross M. Trust in societal factors and vaccine hesitancy in Western Balkans. European Journal of Public Health. 2022 Oct;32(Supplement_3):ckac130-156.
• Matovic Miljanovic S, Cvjetkovic S, Jeremic-Stojkovic V, Mandic-Rajcevic S. COVID-19 vaccine hesitancy in five Western Balkan countries. European Journal of Public Health. 2022 Oct;32(Supplement_3):ckac129-736.
• Mandić-Rajčević S, Dinić M, Tripković K, Šantrić Milićević M. Disaster response and COVID-19: was safety and health a priority among medical doctors in Serbia?. European Journal of Public Health. 2021 Oct;31(Supplement_3):ckab164-223.

Saradnja sa institucijama i učešće u radnim grupama

• Organizacija svetskog događaja o formiranju kurikuluma iz upravljanja infodemijom u saradnji sa Svetskom zdravstvenom organizacijom (mart 2023. godine)
• Organizacija edukacije iz upravljanja infodemijom u saradnji sa Svetskom zdravstvenom organizacijom (decembar 2022. godine)
• Crveni krst Srbije – Naučno stručna i poslovno-tehnička saradnja (od novembra 2022. godine)
• Učešće u radnoj grupi Svetske zdravstvene organizacije „Ethics of social listening and infodemic management“

Naučno-istraživačka laboratorija / Scientific Research Laboratory

Laboratorija za jačanje kapaciteta i performansi zdravstvenog sistema i kadrova za zdravstvenu pravičnost

Laboratory for strengthening the capacity and performance of the health system and personnel for health equity

Rukovodilac: Prof. dr Milena Šantrić Milićević
Director: Prof dr Milena Santric Milicevic

Kontakt / Contact details:
Telefon / Phone: +381-11-2685-451
e: milena.santric-milicevic@med.bg.ac.rs
w: www.mfub.bg.ac.rs
Adresa: Dr Subotića 15, 11000 Medicinski fakultet Univerziteta u Beogradu, Institut za socijalnu medicinu
Address: Dr Subotića 15, 11000 Faculty of Medicine, University of Belgrade, Institute of Social Medicine, Belgrade, Serbia

Godina početka rada/ Established: 2023

Oblast rada / Field of work:

• zdravstveni sistem i službe / health care system and services
• ljudski resursi za zdravlje / human resources for health,
• zdravstvena pravičnost / health equity.

Vrsta aktivnosti* / Type of activity:*

• istraživanja i generisanje relevantnih dokaza / research and generating relevant evidence
• projektni i konsultativni rad / project and consultative work
• procene i evaluacije / assessments and evaluations,
• informisanje i edukacija / information and education,
• planiranje, optimizacija kapaciteta i performansi / planning, capacity and performance optimization
• naučno stručno umrežavanje i organizacija skupova / scientific professional networking and organization of meetings

*povezane su sa Ciljevima održivog razvoja: 3 – Dobro zdravlje i blagostanje, 10 – Smanjenje nejednakosti i 16 – Mir, pravda i jake institucije
* linked to the SDGs: 3 – Good health and well-being, 10 – Reducing inequalities and 16 – Peace, justice and strong institutions

Istraživači / Researchers:

• Prof. dr Milena Šantrić Milićević / Prof. Dr Milena Santric Milicevic
• Prof. dr Vesna Bjegović Mikanović / Prof. Dr Vesna Bjegovic-Mikanovic
• Prof. dr Dejana Vuković / Prof. Dr Dejana Vukovic
• Prof. dr Janko Janković / Prof. Dr Janko Jankovic
• Asis. dr Aleksandar Stevanović / Asist. Dr Aleksandar Stevanovic

Istraživači – saradnici / Researchers – Collaborators:

• nastavnici i saradnici Instituta za socijalnu medicinu / Faculty and associates of the Institute of Social Medicine
• nastavnici i saradnici Medicinskog fakulteta u Beogradu / Faculty and associates of the Faculty of Medicine in Belgrade

Partneri u zemlji i inostranstvu / Partners in the country & abroad:

• institucije u sklopu i van Univerziteta u Beogradu / institutions within and outside the University of Belgrade
• međunarodne organizacije / international organizations
• vladine organizacije / government organizations
• privatna praksa / private practice
• nevladine organizacije / non-governmental organizations
• civilna društva / civil society
• pacijenti, građani / patients, citizens.

Doktorandi / PhD students

• Sanja Stanković / Sanja Stankovic
• Milan Dinić / Milan Dinic

Volonteri / Volunteers

• Studenti / Students

Odabarani Projekti / Konsulativni rad
Selected Projects / Consulative work

Godina /Year	Naziv/Title	Autputi / Deliverables
2023	WHO Europe Mission on Primary Health Care in Serbia	Eksperske konsultatcije- Svetska zdravstvena organizacija: okrugli sto na temu primarne zdravstvene zaštite, Institut za javno zdravlje Srbije
2022	WHO Collaborating Centers on Refugee and Migrant Health Meeting	Izrada plana i programa saradnje SZO Kolaborativnih cenatra
2021-2023	EC/EU Project. AHEAD – ‘Action for Health and Equity Addressing Medical Deserts’, www.ahead.health	Metodologijom zasnovanom na Teoriji promene, participatornom pristupu i izgradnji konsenzusa: Kreiran je skup indikatora za identifikaciju i praćenje razvoja medicinskih pustinja (MP) Razvijeni su validirani alati za mapiranje MP, i mape MP na NUTS3 nivou – stvrena je osnova za razvoj softvera MP Validiran je skup prioritetnih mera za rešavanje MP na nacionalnom nivou i u Evropi U Evropskom parlamentu verifikovane su politike i aktivnosti za strateško i operativno rešavanje MP na nacionalnom nivou i u Evropi
2022 – i dalje	European Health Management Association — Special Interest Group for South Eastern Europe	Kontinuirane ekspertske konsultacije za pitanja menadžmenta i kadrovima u zdravstvenom sektoru u zemljama Jugoistočne Evrope
2021-2023.	Pillars of Health – “EU level Health workforce mobility”. The WEMOS Foundation Netherlands	Metodologijom zasnovanom na Teoriji promene, DEPLESET kontekst analizi i Stejkholder analizi, napravene su osnove za zagovaranje rešavanja pitanja neželjenih posledica mobilnosti zdravstvenih radnike u Srbiji i Evropi: Urađen je Opis aktuelnog konteksta zemlje, migratorni profil i indikatoriza praćenje  zdravstvenih radnika u zemlji Ilustrovani su infografici o razlozima migracija i mogućnostima za rešavanje neženjenih migratornih tokova U procesu zagovaranja, predstavljene su novine u  vezi sa SZO Etičkim kodeksom za regrutovanje zdravstvenih radnika Istaknute su smernice Evropske regulative kojima se podržava etičko regrutovanje kadrova, kao osnova izgradnje politike za migracije zdravstvenih kadrova.
2020-2023	PRICOV-19 – Quality of care and patient safety in primary care practices in times of a pandemic	Komparativna analiza kvaliteta, bezbednosti, performansi, najboljih praksi i mentalnog zdravlja lekara u službama u primarnoj zdravstvenoj zaštiti tokom i pre pandemije – istraživački projekat u 38 zemalja Evrope.
2021-2023.	The Burden of Disease due to COVID-19. Towards a harmonization of population health metrics for the surveillance of dynamic outbreaks. The German Federal Ministry of Health.	Istraživački projekat u 17 zemalja Evrope, Centralne Azije i Južnog Kavkaza – Jedinstvenom i harmonizovanom metodologijom zasnovanom na Opterećenju društva bolešću – procenjen je efekat kovid-19 pandemije na međunarodnom,  nacionalnom i lokalnom nivou.
2019-2023.	The EU COST Action “European Burden of Disease Network” (burden-eu) CA18218. The Horizon 2020 Framework Programme of the European Union	Popularizovana je metodologija  Opterećenja društva bolešću  u Srbiji, značajno je povećan broj pofesionalaca koji je pohađao edukacije i ima publikacije. Urađeni su vodiči i škole za procenu Opterećenja druptva bolešću i nepravičnosti u zdravlju.
2019	Rapid assessment of the situation and recommendations for the migration of healthcare professionals from Central and Eastern Europe to Western Europe. OSF New York:	Urađen je sveobuhvatni opis aktuelnog konteksta zemlje  za migratorni profil zdravstvenih radnika sa indikatorima za praćenje  u zemlji.
2018 – present	WHO. Global Health Workforce Network	Priručnik za prikupljanje podataka, izradu indikatora i evaluaciju politika o i pravičnosti u pristupu zdravstvenoj službi i dostupnosti zdravstvenih radnika.
2018-2022	EC-EU/JAHEE WP7 Migration and Health	Urađen je sveobuhvatni profil zdravlja migranata
2017 – present	EUPHA – Health Workforce Research Board	Kontinuirana kolaboracija sa međunarodno priznatim ekspertima u vezi aktuelnih kadrovskih pitanja
2016 – present:	IHME Global Burden of Disease Network of Collaborators.	Istraživanja o zdravstvenim nejednakostima, zdravstvenim kadrovima, finansiranju, uslugama i sistemu.
2011- present	WHO EUROPE- Human Resource for Health. A technical expert from Serbia	Tehničke konsultatcije u vezi podataka, indikatora i migracija zdravstvenih kadrova
2019	WHO Expert Consultation on WISN Implementation, Istanbul, Turkey. HWF/DEK/WISN	Optimizacija sistema – procenjen je potreban broj zdravstvenih kadrova na osnovu radnog opterećenja
2019	WHO, ECFMG® , GHWN. Health Workforce Regulation and Accreditation.	Mapirana je usklađenost regulative sa međunarodnim standardima za akreditaciju medicisnkih visoko obrazovnih programa
2016-2018	WHO / Coalition of Partners. Strengthen public health capacities and services in the European Region	Kontinuirane ekspertske konsultacije za jačanje javnozdravstvenih kapaciteta i usluga u regionu Evrope
2018	WHO/Europe Temporary Advisor on HRH at A High-Level Meeting: Accelerating Implementation of the International Health Regulations (2005) and Strengthening Emergency Preparedness in the WHO European Region	Kontinuirane ekspertske konsultacije za kadrovska pitanja, i kompentencije za implementaciju Međunarodnog zdravstvenog pravilnika i jačanje pripravnosti za krize u SZO regionu Evrope.
2016-2017	WHO/Europe Consultant to Lead Specific Actions in the Public Health Laboratory Network Optimization Project in Ukraine	Optimizacija javnozdravstvenih laboratorija u Ukrajini – Urađena je analiza, strateški i operativni plan i edukacije.
2017- 2018	ECDC – European Centres for Diseases and Control. Technical Advisory Group on Capacity and Training Needs Assessment	Kontinuirane ekspertske konsultacije za jačanje kapaciteta i kompetencija kadrova za javno zdravlje – urađena je procena potreba za edukacijom zdravstvenom sektoru u zemljama Evrope
2017	WHO/Europe & Ministry of Health of Serbia: Assessment of HRH in the Republic of Serbia. WHO/Europe HRH Consultant	Urađena je sveobuhvatna analiza i opis zdravstvenih radnika  uz 88 indikatora: upravljanje, finansiranje, jednakost, performanse, regulativa, i planiranje.
2016	WHO/EUROPE & SEEHN: Human Resources for Public Health Services, Banja Luka, Bosnia and Herzegovina	Analiza najboljih praksi javnozdravstvenih radnika u zdravstvenom sektoru u zemljama Jugoistočne Evrope.
2012	World Bank – DILS project	Edukacija i nadzor nad izradom strateških planova domova zdravlja

Odabrani radovi / Selected publications:

• Russo, G., Perelman, J., Zapata, T. et al.The layered crisis of the primary care medical workforce in the European region: what evidence do we need to identify causes and solutions?. Hum Resour Health 21, 55 (2023).  https://doi.org/10.1186/s12960-023-00842-4
• Alonso-Garbayo A, Bruno-Tomé A, Ellington K, Massiah S, Šantrić Milićević M, Pálsdóttir B, Scheerens C, Scotter CDP. Health workforce access: opening an HRH equity assessment lens. Chapter 8 in Strengthening the collection, analysis and use of health workforce data and information: a handbook. Geneva: World Health Organization; 2022. Licence: CC BY-NC-SA 3.0 IGO. https://apps.who.int/iris/bitstream/handle/10665/365680/9789240058712-eng.pdf?sequence=1&isAllowed=y
• Collins C, Clays E, Van Poel E, Cholewa J, Tripkovic K, Nessler K, de Rouffignac S, Šantrić Milićević M, Bukumiric Z, Adler L, Ponsar C, Murauskiene L, Ožvačić Adžić Z, Windak A, Asenova R, Willems S. Distress and Wellbeing among General Practitioners in 33 Countries during COVID-19: Results from the Cross-Sectional PRICOV-19 Study to Inform Health System Interventions. Int J Environ Res Public Health. 2022 May 6;19(9):5675. doi: 10.3390/ijerph19095675.
• Collins C, Van Poel E, Šantrić Milićević M, Tripkovic K, Adler L, Bjerve Eide T, Murauskiene L, Windak A, Nessler K, Tahirbegolli B, Willems S. Practice and System Factors Impact on Infection Prevention and Control in General Practice during COVID-19 across 33 Countries: Results of the PRICOV Cross-Sectional Survey.Int J Environ Res Public Health. 2022 Jun 26;19(13):7830. doi: 10.3390/ijerph19137830.
• GBD 2019 Human Resources for Health Collaborators (Haakenstad A…Santric-Milicevic MM…Lozano R). Measuring the availability of humanresources for health and its relationship to universal health coverage for 204 countries and territories from 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2022 Jun 4;399(10341):2129-2154. doi: 10.1016/S0140-6736(22)00532-3.
• GBD 2019 Cancer Risk Factors Collaborators. The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2022;400(10352):563-591. doi:10.1016/S0140-6736(22)01438-6
• Santric-Milicevic M, Stevanovic A, Popovac N, et al. Participation in Bullying and Associated Health Characteristics, Risk Factors and Leisure Activities: A Profile of School-Age Children in Serbia. Int J Environ Res Public Health. 2022;19(15):9159. Published 2022 Jul 27. doi:10.3390/ijerph19159159
• Stankovic S, Santric Milicevic M. Use of the WISN method to assess the health workforce requirements for the high-volume clinical biochemical laboratories. Hum Resour Health. 2022 Jan 28;19(Suppl 1):143. doi: 10.1186/s12960-021-00686-w.
• Tripković K, Šantrić Milićević M, Mandić Miladinović M, Kovačević L, Bjegović Mikanović V, Vuković D. Implementation of the Workload Indicators of Staffing Need (WISN) Method in Determining Staff Requirements in Public Health Laboratories in Serbia. Disaster Med Public Health Prep. 2022 Feb;16(1):71-79. doi: 10.1017/dmp.2020.133.
• Tripković, K., Šantrić-Milićević, M., Vasić, M., Živković-Šulović, M., Odalović, M., Mijatović-Jovanović, V., & Bukumirić, Z. (2021). Factors Associated with Intention of Serbian Public Health Workers to Leave the Job: A Cross-Sectional, Population-Based Study. International journal of environmental research and public health, 18(20), 10652. https://doi.org/10.3390/ijerph182010652
• Global Burden of Disease 2020 Health Financing Collaborator Network (2021). Tracking development assistance for health and for COVID-19: a review of development assistance, government, out-of-pocket, and other private spending on health for 204 countries and territories, 1990-2050. Lancet (London, England), 398(10308), 1317–1343. https://doi.org/10.1016/S0140-6736(21)01258-7
• Charalampous, P., Haagsma, J. A., Jakobsen, L. S., Gorasso, V., Noguer, I., Padron-Monedero, A., Sarmiento, R., Santos, J. V., McDonald, S. A., Plass, D., Wyper, G. M. A., Assunção, R., von der Lippe, E., Ádám, B., AlKerwi, A., Arabloo, J., Baltazar, A. L., Bikbov, B., Borrell-Pages, M., Brus, I., … Pires, S. M. (2023). Burden of infectious disease studies in Europe and the United Kingdom: a review of methodological design choices. Epidemiology and infection, 151, e19. https://doi.org/10.1017/S0950268823000031
• Global Burden of Disease Health Financing Collaborator Network (2019). Past, present, and future of global health financing: a review of development assistance, government, out-of-pocket, and other private spending on health for 195 countries, 1995-2050. Lancet (London, England), 393(10187), 2233–2260. https://doi.org/10.1016/S0140-6736(19)30841-4
• GBD 2019 Healthcare Access and Quality Collaborators (2022). Assessing performance of the Healthcare Access and Quality Index, overall and by select age groups, for 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019. The Lancet. Global health, 10(12), e1715–e1743. https://doi.org/10.1016/S2214-109X(22)00429-6
• GBD 2019 Human Resources for Health Collaborators (2022). Measuring the availability of human resources for health and its relationship to universal health coverage for 204 countries and territories from 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet (London, England), 399(10341), 2129–2154. https://doi.org/10.1016/S0140-6736(22)00532-3
• Global Burden of Disease 2021 Health Financing Collaborator Network (2023). Global investments in pandemic preparedness and COVID-19: development assistance and domestic spending on health between 1990 and 2026. The Lancet. Global health, 11(3), e385–e413. https://doi.org/10.1016/S2214-109X(23)00007-4
• Bjegovic-Mikanovic, V., Vasic, M., Vukovic, D., Jankovic, J., Jovic-Vranes, A., Santric-Milicevic, M., Terzic-Supic, Z., & Hernandez-Quevedo, C. (2019). Serbia: Health System Review. Health systems in transition, 21(3), 1–211.
• Dinić, M., Šantrić Milićević, M., Mandić-Rajčević, S., & Tripković, K. (2021). Health workforce management in the context of the COVID-19 pandemic: A survey of physicians in Serbia. The International journal of health planning and management, 36(S1), 92–111. https://doi.org/10.1002/hpm.3141
• Dikic, M., Nikolic, D., Todorovic, J., Terzic-Supic, Z., Kostadinovic, M., Babic, U., Gacevic, M., & Santric-Milicevic, M. (2019). Alignment of Perceived Competencies and Perceived Job Tasks among Primary Care Managers. Healthcare (Basel, Switzerland), 8(1), 9. https://doi.org/10.3390/healthcare8010009
• Gacevic, M., Santric Milicevic, M., Vasic, M., Horozovic, V., Milicevic, M., & Milic, N. (2018). The relationship between dual practice, intention to work abroad and job satisfaction: A population-based study in the Serbian public healthcare sector. Health policy (Amsterdam, Netherlands), 122(10), 1132–1139. https://doi.org/10.1016/j.healthpol.2018.09.004
• Santric-Milicevic, M., Vasic, M., Vasic, V., Zivkovic-Sulovic, M., Cirovic, D., Lackovic, M., & Boskovic, N. (2020). Uptake of Health Care Services by Refugees: Modelling a Country Response to a Western Balkan Refugee Crisis. Healthcare (Basel, Switzerland), 8(4), 560. https://doi.org/10.3390/healthcare8040560